PD 168077 maleate

Key Product Details

Product Description

PD 168077 maleate is a potent D₄ dopamine receptor agonist (K_i = 8.7 nM) with > 400-fold selectivity over D₂ and > 300-fold selectivity versus D₃ subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo.

Product Specifications for PD 168077 maleate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PD 168077 maleate

The following data is based on the product molecular weight 450.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.22 mL	11.10 mL	22.20 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
10 mM	0.22 mL	1.11 mL	2.22 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 8 publications citing the usage of this product.

• Glase Substituted [(4-phenylpiperazinyl)methyl]benzamides: selective DA D₄ agonists. J.Med.Chem. 1997 PMID: 9191952
• Gu Activation of DA D₄ receptors induces synaptic translocation of Ca²⁺/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol.Pharmacol. 2006 PMID: 16365279
• Clifford and Waddington Topographically based search for an "Ethogram" among a series of novel D₄ DA receptor agonists and antagonists. Neuropsychopharmacology 2000 PMID: 10731629

Product Documents for PD 168077 maleate