PD 168077 maleate

  ( 5 citations )    
Product Datasheet
Catalog Number:1065
Chemical Name:N-(Methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamide maleate
Product Details
Citations (5)
Reviews
Biological Activity
A potent D4 dopamine receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2 and > 300-fold selectivity versus D3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo.
Technical Data
  • M.Wt:
    450.49
  • Formula:
    C20H22N4O.C4H4O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99
  • Storage:
    Desiccate at -20°C
  • CAS No:
    630117-19-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PD 168077 maleate include:

5 Citations: Showing 1 - 5
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  1. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell  2017;16(6):1323
  2. Neurochemical arguments for the use of dopamine D4 receptor stimulation to improve cognitive impairment associated with schizophrenia.
    Authors: Huang
    Pharmacol Biochem Behav  2017;157:16
  3. Activation of D4 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells.
    Authors: Chen Et al.
    J Biol Chem  2015;65:153
  4. Restoration of glutamatergic transmission by dopamine D4 receptors in stressed animals.
    Authors: Yuen Et al.
    J Biol Chem  2013;288:26112
  5. Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.
    Authors: Graziane Et al.
    Circ Res  2009;284:8329

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