PD 168077 maleate
Chemical Name: N-[[4-(2-Cyanophenyl)-1-piperazinyl]methyl]-3-methylbenzamide maleate
Biological ActivityPD 168077 maleate is a potent D4 dopamine receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2 and > 300-fold selectivity versus D3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Topographically based search for an "Ethogram" among a series of novel D4 DA receptor agonists and antagonists.
Clifford and Waddington
Activation of DA D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons.
Gu et al.
Substituted [(4-phenylpiperazinyl)methyl]benzamides: selective DA D4 agonists.
Glase et al.
Citations for PD 168077 maleate
The citations listed below are publications that use Tocris products. Selected citations for PD 168077 maleate include:
7 Citations: Showing 1 - 7
Pharmacological activation of dopamine D4 receptor modulates morphine-induced changes in the expression of GAD65/67 and GABAB receptors in the basal ganglia.
Authors: Negrete-Díaz Et al.
Is DA transporter-mediated DArgic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel DA transporter variant Val559 transgenic mouse model.
Authors: Dai Et al.
J Neurodev Disord 2017;9:38
DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
Aging Cell 2017;16(6):1323
Neurochemical arguments for the use of DA D4 receptor stimulation to improve cognitive impairment associated with schizophrenia.
Pharmacol Biochem Behav 2017;157:16
Activation of D4 DA receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells.
Authors: Chen Et al.
J Biol Chem 2015;65:153
Restoration of glutamatergic transmission by DA D4 receptors in stressed animals.
Authors: Yuen Et al.
J Biol Chem 2013;288:26112
DA D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.
Authors: Graziane Et al.
Circ Res 2009;284:8329
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