Catalog Number: 1065
Chemical Name: N-(Methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamide maleate
Biological Activity
A potent D4 dopamine receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2 and > 300-fold selectivity versus D3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo.
Technical Data
  • M.Wt:
    450.49
  • Formula:
    C20H22N4O.C4H4O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    630117-19-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Substituted [(4-phenylpiperazinyl)methyl]benzamides: selective dopamine D4 agonists.
    Glase et al.
    J.Med.Chem., 1997;40:1771
  2. Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons.
    Gu et al.
    Mol.Pharmacol., 2006;69:813
  3. Topographically based search for an "Ethogram" among a series of novel D4 dopamine receptor agonists and antagonists.
    Clifford and Waddington
    Neuropsychopharmacology, 2000;22:538
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PD 168077 maleate include:

5 Citations: Showing 1 - 5
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  1. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell 2017;16(6):1323
  2. Neurochemical arguments for the use of dopamine D4 receptor stimulation to improve cognitive impairment associated with schizophrenia.
    Authors: Huang
    Pharmacol Biochem Behav 2017;157:16
  3. Activation of D4 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells.
    Authors: Chen Et al.
    J Biol Chem 2015;65:153
  4. Restoration of glutamatergic transmission by dopamine D4 receptors in stressed animals.
    Authors: Yuen Et al.
    J Biol Chem 2013;288:26112
  5. Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism.
    Authors: Graziane Et al.
    Circ Res 2009;284:8329

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