A potent D4
dopamine receptor agonist (Ki
= 8.7 nM) with > 400-fold selectivity over D2
and > 300-fold selectivity versus D3
subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo
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Substituted [(4-phenylpiperazinyl)methyl]benzamides: selective dopamine D4 agonists.
Glase et al.
Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons.
Gu et al.
Topographically based search for an "Ethogram" among a series of novel D4 dopamine receptor agonists and antagonists.
Clifford and Waddington
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