Catalog Number: 3529
Chemical Name: 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one dihydrochloride
Biological Activity
Potent and selective dopamine D4 receptor antagonist (Ki values are 8.8 and 1842 nM at D4 and D2 receptors respectively). Reverses amphetamine-stimulated locomotion in vivo and is orally active.
Technical Data
  • M.Wt:
    422.39
  • Formula:
    C22H27N3O.2HCl
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    210688-56-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Isoindolinone enantiomers having affinity for the dopamine D4 receptor.
    Belliotti et al.
    Bioorg.Med.Chem.Lett., 1998;8:1499

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