Chemical Name: 9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione
Biological ActivityPotent and selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC50 values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC50 values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μM for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively. Also sensitizes hESCs to BMP4 to induce differentiation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation.
Squire et al.
4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenylring substitutions.
Palmer et al.
Discovery of a small-molecule BMP sensitizer for human embryonic stem cell differentiation.
Feng et al.
Cell Rep., 2016;15:2063
Citations for PD 407824
The citations listed below are publications that use Tocris products. Selected citations for PD 407824 include:
3 Citations: Showing 1 - 3
Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine.
Authors: Kishikawa Et al.
Cisplatin sensitivity mediated by WEE1 and CHK1 is mediated by miR-155 and the miR-15 family.
Authors: Pouliot Et al.
Cancer Res 2012;72:5945
Synthetic lethal RNAi screening identifies sensitizing targets for gemcit. therapy in pancreatic cancer.
Authors: Azorsa Et al.
J Transl Med 2009;7:43
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