Selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC50
values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC50
values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μ
M for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively.
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Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation.
Squire et al.
4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenylring substitutions.
Palmer et al.
The citations listed below are publications that use Tocris products. Selected citations for PD 407824 include:
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