PD 407824

Catalog # Availability Size / Price Qty
2694/1
2694/10
PD 407824 | CAS No. 622864-54-4 | Checkpoint Kinase Inhibitors
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Description: Potent and selective inhibitor of Chk1 and Wee1

Chemical Name: 9-Hydroxy-4-phenyl-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

Purity: ≥98%

Product Details
Citations (3)
Reviews

Biological Activity

Potent and selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC50 values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC50 values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μM for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively. Also sensitizes hESCs to BMP4 to induce differentiation.

Technical Data

M.Wt:
328.32
Formula:
C20H12N2O3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
622864-54-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for PD 407824

The citations listed below are publications that use Tocris products. Selected citations for PD 407824 include:

3 Citations: Showing 1 - 3

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