PD 407824

Key Product Details

Product Description

PD 407824 is a potent and selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC₅₀ values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC₅₀ values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μM for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively. Also sensitizes hESCs to BMP4 to induce differentiation.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PD 407824

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PD 407824

The following data is based on the product molecular weight 328.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.05 mL	15.23 mL	30.46 mL
5 mM	0.61 mL	3.05 mL	6.09 mL
10 mM	0.30 mL	1.52 mL	3.05 mL
50 mM	0.06 mL	0.30 mL	0.61 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Palmer 4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenylring substitutions. J.Med.Chem. 2006 PMID: 16884302
• Feng Discovery of a small-molecule BMP sensitizer for human embryonic stem cell differentiation. Cell Rep. 2016 PMID: 27210748
• Squire Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation. Structure 2005 PMID: 15837193

Product Documents for PD 407824