Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC
M). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G
arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal. Also available as part of the
MAPK Cascade Inhibitor Tocriset™
MAPK Inhibitor Tocriset™
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The citations listed below are publications that use Tocris products.
Selected citations for PD 98059 include:
Citations: Showing 1 -
Filter your results:
Pancreatic insulin content regulation by the estrogen receptor ER alpha.
Authors: Alonso-Magdalena Et al.
PLoS One ;3:e2069
cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells.
Authors: Inda Et al.
Sci Rep 2017;7:1944
G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells
Authors: Rao and Herr
Biochim Biophys Acta 2017;1864(7):1318
Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation.
Brain Res 2017;1663:132
B positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cellslacking functional GABA B receptors
Authors: Olianas Et al.
European Journal of Pharmacology 2016;794:135
Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
Authors: Mou Et al.
Cell: Stem Cell 2016;19:217
α-glycyrrhetinic acid lethality for neuroblastoma cells via de-regulating the Beclin-1/Bcl-2 complex and inducing apoptosis.
Authors: Rahman Et al.
Biochemical Pharmacology 2016;117:97
Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
Authors: Tozzi Et al.
Front Cell Neurosci 2015;9:192
The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer.
Authors: Sahay Et al.
Int J Mol Med 2015;6:20604
Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets.
Authors: Edén Et al.
Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma.
Authors: Koerber Et al.
MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy.
Authors: Li Et al.
Brain Behav.Immun. 2015;49:255
MFG-E8 inhibits neutrophil migration through αvβ3-integrin-dependent MAP kinase activation.
Authors: Aziz Et al.
J Neuroinflammation 2015;36:18
Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
Authors: Zhu Et al.
PLoS One 2015;35:621
Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.
Authors: Gudasheva Et al.
Int J Mol Sci 2015;22:106
Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
Authors: Lin Et al.
Exp Hematol Oncol 2015;16:5555
NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1.
Authors: Vuong Et al.
J Neurosci 2015;12:229
Synergistic effects of high dietary calcium and exogenous parathyroid hormone in promoting osteoblastic bone formation in mice.
Authors: Feng Et al.
Br J Nutr 2015;113:909
The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
Authors: Smith Et al.
Mol Cancer 2015;10:e0136546
Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation.
Authors: Yu Et al.
PLoS One 2014;9:e112989
Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells.
Authors: Fernández-Pisonero Et al.
PLoS One 2014;9:e109081
Distinct signalling pathways of murine histamine H1- and H4-receptors expressed at comparable levels in HEK293 cells.
Authors: Beermann Et al.
PLoS One 2014;9:e107481
Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α.
Authors: Gonsalves Et al.
Am J Hematol 2014;89:273
Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.
Authors: Elabd Et al.
Nat Commun 2014;5:4082
Resolvin D2 supports MCF-7 cell proliferation via activation of estrogen receptor.
Authors: Al-Zaubai Et al.
J Pharmacol Exp Ther 2014;351:172
Central SDF-1/CXCL12 expression and its cardiovascular and sympathetic effects: the role of angiotensin II, TNF-α, and MAP kinase signaling.
Authors: Wei Et al.
Am J Physiol Heart Circ Physiol 2014;307:H1643
GABA(A) receptor pi (GABRP) stimulates basal-like breast cancer cell migration through activation of extracellular-regulated kinase 1/2 (ERK1/2).
Authors: Sizemore Et al.
J Biol Chem 2014;289:24102
Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation.
Authors: Morelli Et al.
BMC Cancer 2014;14:921
Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.
Authors: Akhtar Et al.
PLoS One 2013;8:e67813
Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
Authors: Wang Et al.
Effects of Y27632 on keratinocyte procurement and wound healing.
Authors: Gandham Et al.
PLoS One 2013;38:782
Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.
Authors: Kim Et al.
J Biol Chem 2013;288:22693
A Taiwanese Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription Factor-3 in Human Hepatoma Cells.
Authors: Suk Et al.
Evid Based Complement Alternat Med 2013;2013:658370
Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.
Authors: Teng Et al.
Toxicol Sci 2013;131:71
Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
Authors: Ahmadiantehrani and Ron
J Neurochem 2013;
Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
Authors: Gangoiti Et al.
Inhibition of α-SMA by the ectodomain of FGFR2c attenuates lung fibrosis.
Authors: Ju Et al.
J Pharmacol Exp Ther 2012;18:992
Curcumin inhibits glutamate release from rat prefrontal nerve endings by affecting vesicle mobilization.
Authors: Lin Et al.
J Biomed Sci 2012;13:9097
Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide.
Authors: Kovac Et al.
J Biomed Sci 2011;8:139
Saccharomyces boulardii improves intestinal cell restitution through activation of the α2β1 integrin collagen receptor.
Authors: Canonici Et al.
Exp Cell Res 2011;6:e18427
Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus.
Authors: Mockett Et al.
J Neurosci 2011;31:7380
Reversible differentiation of myofibroblasts by MyoD.
Authors: Hecker Et al.
Br J Pharmacol 2011;317:1914
Wnt5a-dopamine D2 receptor interactions regulate dopamine neuron development via extracellular signal-regulated kinase (ERK) activation.
Authors: Yoon Et al.
PLoS One 2011;286:15641
Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells.
Authors: He Et al.
Mol Med 2011;18:39
IL-32gamma induces the maturation of dendritic cells with Th1- and Th17-polarizing ability through enhanced IL-12 and IL-6 production.
Authors: Jung Et al.
J Immunol 2011;186:6848
Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway.
Authors: Tsai Et al.
J Nutr 2011;141:2119
Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation.
Authors: Barrio Et al.
Toxicol Sci 2011;123:193
β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
Authors: Meitzen Et al.
J Neurochem 2011;116:984
Hyperactivation of NF-κB via the MEK signaling is indispensable for the inhibitory effect of cAMP on DNA damage-induced cell death.
Authors: Kloster Et al.
Mol Cancer 2011;10:45
Extranuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus.
Authors: Yang Et al.
PLoS One 2010;5:e9851
Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
Authors: Huang Et al.
J Neurosci 2010;30:6080
Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension.
Authors: Wong Et al.
Circ Res 2010;107:984
Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
Authors: Roselli Et al.
PLoS One 2009;4:e6011
BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.
Authors: Zhong Et al.
J Neurosci 2009;29:9977
Glucocorticoid effects on memory consolidation depend on functional interactions between the medial prefrontal cortex and basolateral amygdala.
Authors: Roozendaal Et al.
J Neurosci 2009;29:14299
PLZF is a regulator of homeostatic and cytokine-induced myeloid development.
Authors: Doulatov Et al.
Genes Dev 2009;23:2076
The kinase inhibitors sunitinib and sorafenib differentially affect NK cell antitumor reactivity in vitro.
Authors: Krusch Et al.
J Immunol 2009;183:8286
Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1.
Authors: Yeligar Et al.
J Immunol 2009;183:5964
Soy phytoestrogens are neuroprotective against stroke-like injury in vitro.
Authors: Schreihofer and Redmond
J Endocrinol 2009;158:602
Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells.
Authors: Cho Et al.
J Vet Sci 2009;10:23
Mitogen-activated protein kinases mediate upregulation of hypothalamic angiotensin II type 1 receptors in heart failure rats.
Authors: Wei Et al.
Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells.
Authors: Jung Et al.
Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53.
Authors: Kim Et al.
J Biol Chem 2008;283:3731
Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds.
Authors: Kim Et al.
Br J Pharmacol 2008;155:814
Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors.
Authors: Zapata Et al.
J Biol Chem 2007;282:35842
IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.
Authors: Chung Et al.
J Endocrinol 2007;194:77
Insulin induces airway smooth muscle contraction.
Authors: Schaafsma Et al.
Int J Mol Sci 2007;150:136
GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis.
Authors: Lin Et al.
J Cell Sci 2007;120:2935
Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt.
Authors: Sunters Et al.
Cancer Res 2006;66:212
Role of glycogen synthase kinase 3 β (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells.
Authors: Alao Et al.
J Biol Chem 2006;5:40
Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest.
Authors: Sarfaraz Et al.
J Biol Chem 2006;281:39480
Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.
Authors: Kauppinen Et al.
Proc Natl Acad Sci U S A 2006;103:7136
Ischemic preconditioning protects by activating prosurvival kinases at reperfusion.
Authors: Hausenloy Et al.
Am J Physiol Heart Circ Physiol 2005;288:H971
Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea.
Authors: Zerani Et al.
J Neuroinflammation 2004;183:279
Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis.
Authors: Martin Et al.
Br J Pharmacol 2003;139:1095
Expand to show all Citations
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQs
Have you used PD 98059?
Submit a Review
Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you
include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image.
Limited to verified customers in USA, Canada and Europe.
Read what people are saying who have used PD 98059.
We have 1 review tested in 1 species: Mouse.
Filter by Ratings
Filter by Applications
Filter by Species
Please scroll the above reviews for more