PD 98059

  ( 75 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1213
Chemical Name:2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Product Details
Citations (75)
Reviews
Biological Activity
Inhibitor of mitogen-activated protein kinase kinase (MKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™.
Technical Data
  • M.Wt:
    267.28
  • Formula:
    C16H13NO3
  • Solubility:
    Soluble to 25 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at RT
  • CAS No:
    167869-21-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PD 98059 include:

75 Citations: Showing 1 - 10
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  1. Pancreatic insulin content regulation by the estrogen receptor ER alpha.
    Authors: Alonso-Magdalena Et al.
    PLoS One  ;3:e2069
  2. cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells.
    Authors: Inda Et al.
    Sci Rep  2017;7:1944
  3. G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells
    Authors: Rao and Herr
    Biochim Biophys Acta  2017;1864(7):1318
  4. Cannabinoid receptor 1 contributes to sprouted innervation in endometrial ectopic growth through mitogen-activated protein kinase activation.
    Authors: Han
    Brain Res  2017;1663:132
  5. The GABAB positive allosteric modulators CGP7930 and GS39783 stimulate ERK1/2 signalling in cellslacking functional GABAB receptors
    Authors: Olianas Et al.
    European Journal of Pharmacology  2016;794:135
  6. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells
    Authors: Mou Et al.
    Cell: Stem Cell  2016;19:217
  7. 18α-glycyrrhetinic acid lethality for neuroblastoma cells via de-regulating the Beclin-1/Bcl-2 complex and inducing apoptosis.
    Authors: Rahman Et al.
    Biochemical Pharmacology  2016;117:97
  8. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  9. The LPA1/ZEB1/miR-21-activation pathway regulates metastasis in basal breast cancer.
    Authors: Sahay Et al.
    Int J Mol Med  2015;6:20604
  10. Tissue factor/factor VIIa signalling promotes cytokine-induced beta cell death and impairs glucose-stimulated insulin secretion from human pancreatic islets.
    Authors: Edén Et al.
    Diabetologia  2015;58:2563
  11. Analysis of the anti-proliferative and the pro-apoptotic efficacy of Syk inhibition in multiple myeloma.
    Authors: Koerber Et al.
    Oncotarget  2015;4:21
  12. MAPK signaling downstream to TLR4 contributes to paclitaxel-induced peripheral neuropathy.
    Authors: Li Et al.
    Brain Behav.Immun.  2015;49:255
  13. MFG-E8 inhibits neutrophil migration through αvβ3-integrin-dependent MAP kinase activation.
    Authors: Aziz Et al.
    J Neuroinflammation  2015;36:18
  14. Different patterns of electrical activity lead to long-term potentiation by activating different intracellular pathways.
    Authors: Zhu Et al.
    PLoS One  2015;35:621
  15. Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.
    Authors: Gudasheva Et al.
    Int J Mol Sci  2015;22:106
  16. Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
    Authors: Lin Et al.
    Exp Hematol Oncol  2015;16:5555
  17. NF-κB transcriptional activation by TNFα requires phospholipase C, extracellular signal-regulated kinase 2 and poly(ADP-ribose) polymerase-1.
    Authors: Vuong Et al.
    J Neurosci  2015;12:229
  18. Synergistic effects of high dietary calcium and exogenous parathyroid hormone in promoting osteoblastic bone formation in mice.
    Authors: Feng Et al.
    Br J Nutr  2015;113:909
  19. The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
    Authors: Smith Et al.
    Mol Cancer  2015;10:e0136546
  20. Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation.
    Authors: Yu Et al.
    PLoS One  2014;9:e112989
  21. Synergy between sphingosine 1-phosphate and lipopolysaccharide signaling promotes an inflammatory, angiogenic and osteogenic response in human aortic valve interstitial cells.
    Authors: Fernández-Pisonero Et al.
    PLoS One  2014;9:e109081
  22. Distinct signalling pathways of murine histamine H1- and H4-receptors expressed at comparable levels in HEK293 cells.
    Authors: Beermann Et al.
    PLoS One  2014;9:e107481
  23. Angiogenic growth factors augment K-Cl cotransporter expression in erythroid cells via hypoxia-inducible factor-1α.
    Authors: Gonsalves Et al.
    Am J Hematol  2014;89:273
  24. Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.
    Authors: Elabd Et al.
    Nat Commun  2014;5:4082
  25. Resolvin D2 supports MCF-7 cell proliferation via activation of estrogen receptor.
    Authors: Al-Zaubai Et al.
    J Pharmacol Exp Ther  2014;351:172
  26. Central SDF-1/CXCL12 expression and its cardiovascular and sympathetic effects: the role of angiotensin II, TNF-α, and MAP kinase signaling.
    Authors: Wei Et al.
    Am J Physiol Heart Circ Physiol  2014;307:H1643
  27. GABA(A) receptor pi (GABRP) stimulates basal-like breast cancer cell migration through activation of extracellular-regulated kinase 1/2 (ERK1/2).
    Authors: Sizemore Et al.
    J Biol Chem  2014;289:24102
  28. Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation.
    Authors: Morelli Et al.
    BMC Cancer  2014;14:921
  29. Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.
    Authors: Akhtar Et al.
    PLoS One  2013;8:e67813
  30. Group II metabotropic glutamate receptor agonist LY379268 regulates AMPA receptor trafficking in prefrontal cortical neurons.
    Authors: Wang Et al.
    Neuroscience  2013;8:e61787
  31. Effects of Y27632 on keratinocyte procurement and wound healing.
    Authors: Gandham Et al.
    PLoS One  2013;38:782
  32. Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.
    Authors: Kim Et al.
    J Biol Chem  2013;288:22693
  33. A Taiwanese Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription Factor-3 in Human Hepatoma Cells.
    Authors: Suk Et al.
    Evid Based Complement Alternat Med  2013;2013:658370
  34. Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.
    Authors: Teng Et al.
    Toxicol Sci  2013;131:71
  35. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem  2013;
  36. Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts.
    Authors: Gangoiti Et al.
    Biochimie  2012;94:597
  37. Inhibition of α-SMA by the ectodomain of FGFR2c attenuates lung fibrosis.
    Authors: Ju Et al.
    J Pharmacol Exp Ther  2012;18:992
  38. Curcumin inhibits glutamate release from rat prefrontal nerve endings by affecting vesicle mobilization.
    Authors: Lin Et al.
    J Biomed Sci  2012;13:9097
  39. Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide.
    Authors: Kovac Et al.
    J Biomed Sci  2011;8:139
  40. Saccharomyces boulardii improves intestinal cell restitution through activation of the α2β1 integrin collagen receptor.
    Authors: Canonici Et al.
    Exp Cell Res  2011;6:e18427
  41. Calcium/calmodulin-dependent protein kinase II mediates group I metabotropic glutamate receptor-dependent protein synthesis and long-term depression in rat hippocampus.
    Authors: Mockett Et al.
    J Neurosci  2011;31:7380
  42. Reversible differentiation of myofibroblasts by MyoD.
    Authors: Hecker Et al.
    Br J Pharmacol  2011;317:1914
  43. Wnt5a-dopamine D2 receptor interactions regulate dopamine neuron development via extracellular signal-regulated kinase (ERK) activation.
    Authors: Yoon Et al.
    PLoS One  2011;286:15641
  44. Stanniocalcin-1 promotes tumor angiogenesis through up-regulation of VEGF in gastric cancer cells.
    Authors: He Et al.
    Mol Med  2011;18:39
  45. IL-32gamma induces the maturation of dendritic cells with Th1- and Th17-polarizing ability through enhanced IL-12 and IL-6 production.
    Authors: Jung Et al.
    J Immunol  2011;186:6848
  46. Carnosic acid induces the NAD(P)H: quinone oxidoreductase 1 expression in rat clone 9 cells through the p38/nuclear factor erythroid-2 related factor 2 pathway.
    Authors: Tsai Et al.
    J Nutr  2011;141:2119
  47. Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation.
    Authors: Barrio Et al.
    Toxicol Sci  2011;123:193
  48. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
  49. Hyperactivation of NF-κB via the MEK signaling is indispensable for the inhibitory effect of cAMP on DNA damage-induced cell death.
    Authors: Kloster Et al.
    Mol Cancer  2011;10:45
  50. Extranuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus.
    Authors: Yang Et al.
    PLoS One  2010;5:e9851
  51. Pharmacological and genetic accumulation of hypoxia-inducible factor-1alpha enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor.
    Authors: Huang Et al.
    J Neurosci  2010;30:6080
  52. Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension.
    Authors: Wong Et al.
    Circ Res  2010;107:984
  53. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways.
    Authors: Roselli Et al.
    PLoS One  2009;4:e6011
  54. BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.
    Authors: Zhong Et al.
    J Neurosci  2009;29:9977
  55. Glucocorticoid effects on memory consolidation depend on functional interactions between the medial prefrontal cortex and basolateral amygdala.
    Authors: Roozendaal Et al.
    J Neurosci  2009;29:14299
  56. PLZF is a regulator of homeostatic and cytokine-induced myeloid development.
    Authors: Doulatov Et al.
    Genes Dev  2009;23:2076
  57. The kinase inhibitors sunitinib and sorafenib differentially affect NK cell antitumor reactivity in vitro.
    Authors: Krusch Et al.
    J Immunol  2009;183:8286
  58. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1.
    Authors: Yeligar Et al.
    J Immunol  2009;183:5964
  59. Soy phytoestrogens are neuroprotective against stroke-like injury in vitro.
    Authors: Schreihofer and Redmond
    J Endocrinol  2009;158:602
  60. Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells.
    Authors: Cho Et al.
    J Vet Sci  2009;10:23
  61. Mitogen-activated protein kinases mediate upregulation of hypothalamic angiotensin II type 1 receptors in heart failure rats.
    Authors: Wei Et al.
    Hypertension  2008;52:679
  62. Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cells.
    Authors: Jung Et al.
    Carcinogenesis  2008;29:713
  63. Inhibition of AMP-activated protein kinase sensitizes cancer cells to cisplatin-induced apoptosis via hyper-induction of p53.
    Authors: Kim Et al.
    J Biol Chem  2008;283:3731
  64. Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds.
    Authors: Kim Et al.
    Br J Pharmacol  2008;155:814
  65. Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors.
    Authors: Zapata Et al.
    J Biol Chem  2007;282:35842
  66. IGF-I inhibition of apoptosis is associated with decreased expression of prostate apoptosis response-4.
    Authors: Chung Et al.
    J Endocrinol  2007;194:77
  67. Insulin induces airway smooth muscle contraction.
    Authors: Schaafsma Et al.
    Int J Mol Sci  2007;150:136
  68. GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis.
    Authors: Lin Et al.
    J Cell Sci  2007;120:2935
  69. Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt.
    Authors: Sunters Et al.
    Cancer Res  2006;66:212
  70. Role of glycogen synthase kinase 3 β (GSK3β) in mediating the cytotoxic effects of the histone deacetylase inhibitor trichostatin A (TSA) in MCF-7 breast cancer cells.
    Authors: Alao Et al.
    J Biol Chem  2006;5:40
  71. Cannabinoid receptor agonist-induced apoptosis of human prostate cancer cells LNCaP proceeds through sustained activation of ERK1/2 leading to G1 cell cycle arrest.
    Authors: Sarfaraz Et al.
    J Biol Chem  2006;281:39480
  72. Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2.
    Authors: Kauppinen Et al.
    Proc Natl Acad Sci U S A  2006;103:7136
  73. Ischemic preconditioning protects by activating prosurvival kinases at reperfusion.
    Authors: Hausenloy Et al.
    Am J Physiol Heart Circ Physiol  2005;288:H971
  74. Ob receptor in rabbit ovary and leptin in vitro regulation of corpora lutea.
    Authors: Zerani Et al.
    J Neuroinflammation  2004;183:279
  75. Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis.
    Authors: Martin Et al.
    Br J Pharmacol  2003;139:1095
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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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