PDD 00017273

Tocris Bioscience | Catalog # 5952

Potent and selective PARG inhibitor; cell permeable
Tocris Bioscience

Key Product Details

Description

Potent and selective PARG inhibitor; cell permeable
View all PARG Inhibitors »

Product Description

PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM). Exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1 BRCA1 WT cells and inhibits cancer cell survival. Cell permeable.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PDD 00017273 is reviewed on the chemical probes website.

Product Specifications for PDD 00017273

Molecular Weight

514.62

Formula

C23H26N6O4S2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide

CAS Number

1945950-21-9

PubChem ID

121398766

InChI Key

IFWUBRBMMNTBRZ-UHFFFAOYSA-N

SMILES

O=C(C1=CC(S(NC2(CC2)C)(=O)=O)=CC=C1N3CC4=CC(C)=NN4C)N(CC5=CN=C(C)S5)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.46 100

Preparing Stock Solutions for PDD 00017273

The following data is based on the product molecular weight 514.62.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.72 mL 19.43 mL
5 mM 0.39 mL 1.94 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 72 publications citing the usage of this product.

Product Documents for PDD 00017273

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PDD 00017273

For research use only

Related Research Areas

Infectious Diseases

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