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PDD 00017273

Catalog #: 5952
4 Citations Datasheet / COA / SDS
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5952/10
5952/1
PDD 00017273 | CAS No. 1945950-21-9 | PARG Inhibitors
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Description: Potent and selective PARG inhibitor; cell permeable

Chemical Name: 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM). Exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1 BRCA1 WT cells and inhibits cancer cell survival. Cell permeable.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PDD 00017273 is reviewed on the chemical probes website.

Technical Data

M.Wt:
514.62
Formula:
C23H26N6O4S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1945950-21-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PDD 00017273

The citations listed below are publications that use Tocris products. Selected citations for PDD 00017273 include:

4 Citations: Showing 1 - 4

  1. Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death.
    Authors: Keuss Et al.
    EMBO J  2019;38
  2. Selective Small Molecule PARG Inhibitor Causes Replication Fork Stalling and Cancer Cell Death.
    Authors: Houl Et al.
    Nat Commun  2019;10:5654
  3. The CHD6 chromatin remodeler is an oxidative DNA damage response factor.
    Authors: Moore Et al.
    Nat Commun  2019;10:241
  4. The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication.
    Authors: Hanzlikova Et al.
    Mol Cell  2018;71:319

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