PDE11A Antibody

Novus Biologicals | Catalog # NB100-61669

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG
View all PDE11A Primary Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-NSFKESMEKSSYSD corresponding to internal region according to NP_001070665.1, NP_001070826.1, NP_001070664.1.

Epitope

NSFKESMEKSSYSD

Specificity

This antibody is expected to recognise all four reported isoforms (NP_058649.3 ; NP_001070665.1; NP_001070826.1; NP_001070664.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for PDE11A Antibody

Western Blot: PDE11A Antibody [NB100-61669]

Western Blot: PDE11A Antibody [NB100-61669]

Western Blot: PDE11A Antibody [NB100-61669] - Analysis of PDE11A antibody using this antibody at 0.01ug/ml in Human Prostate lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Western Blot: PDE11A Antibody [NB100-61669]

Western Blot: PDE11A Antibody [NB100-61669]

Western Blot: PDE11A Antibody [NB100-61669] - (1ug/ml) staining of Human Prostate lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for PDE11A Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:2000

Western Blot

0.5 - 1.5 ug/ml
Application Notes
WB: Approx. 60-65 kDa band observed in human skeletal muscle and human prostate lysates (calculated MW of 65.7 kDa band according to NP_001070826.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: PDE11A

The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.

Long Name

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Alternate Names

EC 3.1.4.35, EC 3.1.4.53

Entrez Gene IDs

50940 (Human)

Gene Symbol

PDE11A

UniProt

NP_058649.3 (Human)

Additional PDE11A Products

Product Documents for PDE11A Antibody

Certificate of Analysis

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Product Specific Notices for PDE11A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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