Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 expressed in CHO

Format

Low Endotoxin, Azide and BSA Free
View all PDGF-C Primary Antibodies »

Product Specifications

Immunogen

PDGFC / VEGFE

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Description

The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

This product is shipped at ambient temperature. Upon receipt, store immediately at -20C or lower for 12 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Patent #: WO2013160359

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Applications for PDGF-C Antibody - Humanized - Low Endotoxin, Azide and BSA Free

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry Panel Builder

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Advanced Features

  • Spectra Viewer - Custom analysis of spectra from multiple fluorochromes
  • Spillover Popups - Visualize the spectra of individual fluorochromes
  • Antigen Density Selector - Match fluorochrome brightness with antigen density
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Flow Cytometry

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Format

Low Endotoxin, Azide and BSA Free

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: PDGF-C

PDGFC, also known as Platelet-derived growth factor C, has 3 isoforms, a 345 amino acid isoform that is 39 kDa, a 282 amino acid isoform that is 32 kDa and a 167 amino acid isoform that is 19 kDa, expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract and retinal pigment epithelia; plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis, wound healing, represents potent mitogen for cells of mesenchymal origin, induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis, can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. This protein is being studied for its involvement in mesangial proliferative glomerulonephritis, proliferative glomerulonephritis, glomerulonephritis, brain cancer, prostate carcinoma, nephropathy, prostatitis, prostate cancer, atherosclerosis, retinitis, melanoma, and carcinoma. The protein has been linked to the cytoskeleton remodeling role of PDGFs in cell migration, development PDGF signaling via MAPK cascades, release of novel PDGFs as latent factors, signal transduction, signaling by PD, focal adhesion, gap junction, regulation of actin cytoskeleton, prostate cancer, and melanoma GF pathways where it interacts with PDGFRB, PDGFRA, PLAT, PLAU, PLAUR, EGFR, ERBB2, FGFR1, FLT1, and FLT4 proteins.

Long Name

Platelet-derived Growth Factor C

Alternate Names

PDGFC

Gene Symbol

PDGFC

UniProt

Q9NRA1

Additional PDGF-C Products

Product Documents for PDGF-C Antibody - Humanized - Low Endotoxin, Azide and BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for PDGF-C Antibody - Humanized - Low Endotoxin, Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

PDGF Family

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Protocols

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FAQs

No product specific FAQs exist for this product.

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