PEP 005

Key Product Details

Product Description

PEP 005 is an activator of protein kinase C (PKC). Exhibits antileukemic activity; induces nuclear translocation of PKCδ, and induces apoptosis in acute myeloid leukemia (AML) cell lines and primary AML blast cells. Also displays antiproliferative effects and induces apoptosis in Colo205 cells. Reactivates latent HIV in cell culture. Also reactivates hypofunctional CD8⁺ T cells during chronic viral infection. Acts as a substrate for multidrug transporter.

Product Specifications for PEP 005

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PEP 005

The following data is based on the product molecular weight 430.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.02 mM	116.14 mL	580.68 mL	1,161.36 mL
0.1 mM	23.23 mL	116.14 mL	232.27 mL
0.2 mM	11.61 mL	58.07 mL	116.14 mL
1 mM	2.32 mL	11.61 mL	23.23 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

• Marro Discovery of small molecules for the reversal of T cell exhaustion. Cell Rep. 2019 PMID: 31801090
• Jiang Synergistic reactivation of latent HIV expression by Ingenol-3-Angelate, PEP005, targeted NF-kB signaling in combination with JQ1 induced p-TEFb activation. PLoS Pathog. 2015 PMID: 26225771
• Hampson PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC. Blood 2005 PMID: 15845901
• Kedei Characterization of the interaction of ingenol-3-angelate with protein kinase C. Cancer Res. 2004 PMID: 15126366
• Li The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature. Cancer Res. 2010 PMID: 20460505
• Benhadji Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells. Br.J.Cancer 2008 PMID: 19034280

Product Documents for PEP 005