PEP 005

Catalog # Availability Size / Price Qty
4054/1
Cat.No. 4054 - PEP 005 | C25H34O6 | CAS No. 75567-37-2
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Description: Protein kinase C activator
Alternative Names: Ingenol 3-angelate

Chemical Name: (2Z)-2-Methyl-2-butenoic acid (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester

Purity: ≥98%

Product Details
Citations (1)
Reviews

Biological Activity

Activator of protein kinase C (PKC). Exhibits antileukemic activity; induces nuclear translocation of PKCδ, and induces apoptosis in acute myeloid leukemia (AML) cell lines and primary AML blast cells. Also displays antiproliferative effects and induces apoptosis in Colo205 cells. Reactivates latent HIV in cell culture. Also acts as a substrate for multidrug transporter.

Technical Data

M.Wt:
430.53
Formula:
C25H34O6
Solubility:
Soluble to 2 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
75567-37-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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Citation for PEP 005

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