PEP 005

  ( 1 citations )    
Product Datasheet
Catalog Number:4054
Alternate Names:Ingenol 3-angelate
Chemical Name:(2Z)-2-Methyl-2-butenoic acid (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-6-yl ester
Product Details
Citations (1)
Reviews
Biological Activity
Activator of protein kinase C (PKC). Exhibits antileukemic activity; induces nuclear translocation of PKCδ, and induces apoptosis in acute myeloid leukemia (AML) cell lines and primary AML blast cells. Also displays antiproliferative effects and induces apoptosis in Colo205 cells. Reactivates latent HIV in cell culture. Also acts as a substrate for multidrug transporter.
Technical Data
  • M.Wt:
    430.53
  • Formula:
    C25H34O6
  • Solubility:
    Soluble to 2 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    75567-37-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PEP 005 include:

1 Citations: Showing 1 - 1

  1. Synergistic reactivation of latent HIV expression by Ingenol-3-Angelate, PEP005, targeted NF-kB signaling in combination with JQ1 induced p-TEFb activation.
    Authors: Jiang Et al.
    PloS Pathog.  2015;11:e1005066

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