PF 04217903 mesylate
Chemical Name: 4-[1-(6-Quinolinylmethyl)-1H-1,2,3-triazolo[4,5-b]pyrazin-6-yl]-1H-pyrazole-1-ethanol mesylate
Biological ActivityHighly selective, high affinity MET inhibitor (Ki = 6-7 nM against wild type c-Met). Displays >1000-fold selectivity for c-Met over a panel of 208 kinases.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-
Cui et al.
Novel therapeutic inhibitors of the c-Met signaling pathway in cancer.
Eder et al.
Clin.Cancer Res., 2009;15:2207
Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors.
Timofeevski et al.
Discovery of small molecule c-Met inhibitors: evolution and profiles of clinical candidates.
Underiner et al.
Anticancer Agents Med.Chem., 2010;10:7
Citations for PF 04217903 mesylate
The citations listed below are publications that use Tocris products. Selected citations for PF 04217903 mesylate include:
2 Citations: Showing 1 - 2
Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF/C-Met signaling pathway.
Authors: Leung Et al.
CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation.
Authors: Bertaux-Skeirik Et al.
PLoS Pathog 2015;11:e1004663
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