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PF 04885614

4916 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4916/10
4916/50
Voltage-gated Sodium Channel Blockers Small Molecule
1 Image
Description: Potent and selective NaV1.8 channel blocker; active in vivo

Chemical Name: 1-Methyl-[1-[4-(4-trifluoromethoxy)phenyl]-imidazol-2-yl]-ethanamine

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.

Technical Data

M.Wt:
285.26
Formula:
C13H14F3N3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract.
    Bagal et al.
    4th RSC/SCI Symp. on Ion Channels as Ther. Targ, 2013;

Product Datasheets

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