Home / Voltage-gated Sodium Channel Blockers / PF 04885614

PF 04885614

4916 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4916/10
4916/50
Cat.No. 4916 - PF 04885614 | C13H14F3N3O
1 Image
Description: Potent and selective NaV1.8 channel blocker; active in vivo

Chemical Name: 1-Methyl-[1-[4-(4-trifluoromethoxy)phenyl]-imidazol-2-yl]-ethanamine

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.

Technical Data

M.Wt:
285.26
Formula:
C13H14F3N3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract.
    Bagal et al.
    4th RSC/SCI Symp. on Ion Channels as Ther. Targ, 2013;

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for PF 04885614

There are currently no reviews for this product. Be the first to review PF 04885614 and earn rewards!

Have you used PF 04885614?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.