PF 04885614

Tocris Bioscience | Catalog # 4916

Potent and selective NaV1.8 channel blocker; active in vivo
Tocris Bioscience

Key Product Details

Description

Potent and selective NaV1.8 channel blocker; active in vivo
View all Voltage-gated Sodium Channel Blockers »

Product Description

PF 04885614 is a potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 04885614

Molecular Weight

285.26

Formula

C13H14F3N3O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-Methyl-1-[4-(4-trifluoromethoxy-phenyl)-1H-imidazol-2-yl]-ethylamine

CAS Number

1480833-70-2

PubChem ID

65459349

InChI Key

AGORGFNWYAUYSU-UHFFFAOYSA-N

SMILES

CC(C)(N)C1=NC(C2=CC=C(OC(F)(F)F)C=C2)=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.53 100
Ethanol 28.53 100

Preparing Stock Solutions for PF 04885614

The following data is based on the product molecular weight 285.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.51 mL 17.53 mL 35.06 mL
5 mM 0.70 mL 3.51 mL 7.01 mL
10 mM 0.35 mL 1.75 mL 3.51 mL
50 mM 0.07 mL 0.35 mL 0.70 mL

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Background References

References are publications that support the biological activity of the product.

  • Bagal Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract. 4th RSC/SCI Symp. on Ion Channels as Ther. Targ

Product Documents for PF 04885614

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 04885614

For research use only

Related Research Areas

Ion Channels and Regulators

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  • PF 04885614 used to understand the modulation of peripheral sensitisation
    Name: Alex Samuel
    Species: Human
    Verified Customer | Posted 01/16/2020
    PF 04885614 as an inhibitor was used to understand the modulation of peripheral sensitisation.
    PF 04885614 4916

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