1.8 inhibitor (IC50
= 53 nM for human NaV
1.8 channel). Exhibits selectivity for hNaV
1.8 over hNaV
1.2 and hNaV
values are 4.2, 7.0, 11, 16 and 27 μ
M respectively). Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Sold for research purposes under agreement from Pfizer Inc.
Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract.
Bagal et al.
4th RSC/SCI Symp. on Ion Channels as Ther. Targ, 2013;