PF 04885614
Chemical Name: 1-Methyl-[1-[4-(4-trifluoromethoxy)phenyl]-imidazol-2-yl]-ethanamine
Purity: ≥98%
Biological Activity
Potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract.
Bagal et al.
4th RSC/SCI Symp. on Ion Channels as Ther. Targ, 2013;
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PF 04885614 as an inhibitor was used to understand the modulation of peripheral sensitisation.