Chemical Name: 1-Methyl-[1-[4-(4-trifluoromethoxy)phenyl]-imidazol-2-yl]-ethanamine
Biological ActivityPotent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract.
Bagal et al.
4th RSC/SCI Symp. on Ion Channels as Ther. Targ, 2013;
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for PF 04885614
There are currently no reviews for this product. Be the first to review PF 04885614 and earn rewards!
Have you used PF 04885614?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image