Chemical Name: 1-Methyl-[1-[4-(4-trifluoromethoxy)phenyl]-imidazol-2-yl]-ethanamine
Biological ActivityPF 04885614 is a potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel). Exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of selective NaV1.8 modulators for the treatment of chronic pain. Abstract.
Bagal et al.
4th RSC/SCI Symp. on Ion Channels as Ther. Targ, 2013;
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PF 04885614 as an inhibitor was used to understand the modulation of peripheral sensitisation.