PF 05089771

Catalog # Availability Size / Price Qty
5931/10
5931/50
PF 05089771 | CAS No. 1430806-04-4 | Voltage-gated Sodium Channel Blockers
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Description: Potent and selective Nav1.7 channel blocker

Chemical Name: 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

Potent and selective Nav1.7 channel blocker (IC50 = 8, 11 and 171 nM for mouse, human and rat Nav1.7, respectively). Exhibits selectivity for Nav1.7 over other Nav1 channels (IC50 values are 0.11, 0.16, 0.85, 10, 11 and 25 μM for Nav1.2, Nav1.6, Nav1.1, Nav1.4, Nav1.3 and Nav1.5, respectively). Also exhibits selectivity over a panel of 81 other ion channels, receptors, enzymes and transporters. Blocks spontaneous firing of inherited erythromelalgia (IEM)-derived iPSC sensory neurons in vitro.

Technical Data

M.Wt:
672.56
Formula:
C18H12Cl2FN5O3S2.C7H8O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1430806-04-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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Citation for PF 05089771

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Study of PF 05089771's Nav1.7 blocking efficacy
By Anonymous on 12/26/2019
Application: Species: Human

The effect of PF-05089771, a selective, peripherally restricted Nav1.7 sodium channel blocker on pain due to diabetic peripheral neuropathy was investigated.


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