PF 06273340

Tocris Bioscience | Catalog # 6115

Potent and selective pan-Trk inhibitor; peripherally restricted
Tocris Bioscience

Key Product Details

Description

Potent and selective pan-Trk inhibitor; peripherally restricted
View all Trk Receptor Inhibitors »

Product Description

PF 06273340 is a potent and selective pan-Trk inhibitor (IC50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). Selective for Trk over a panel of ion channels, receptors and other enzymes. Peripherally restricted. Exhibits efficacy in a rodent model of inflammatory pain. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 06273340

Molecular Weight

479.93

Formula

C23H22ClN7O3

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide

CAS Number

1402438-74-7

PubChem ID

66571548

InChI Key

BPIWZDNVMQQBQX-UHFFFAOYSA-N

SMILES

NC1=NC=C2C(N(C(C)(C)CO)C=C2C(C3=CN=CC(NC(CC4=CC=C(Cl)C=N4)=O)=C3)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 47.99 100

Preparing Stock Solutions for PF 06273340

The following data is based on the product molecular weight 479.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.42 mL 20.84 mL
5 mM 0.42 mL 2.08 mL 4.17 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for PF 06273340

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 06273340

For research use only

Related Research Areas

Receptor Tyrosine Kinases (RTKs)

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  • Assessing the efficacy on cancer cells
    Name: Anonymous
    Assay Type: In Vitro
    Cell Line/Tissue: cancer cell line
    Verified Customer | Posted 09/08/2017
    Measured cancer cell viability upon treatment with this drug at various concentrations including 5 and 10 uM. In addition, compared it to a specific siRNA.

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