Chemical Name: 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide
Biological ActivityPF 184 is a potent and selective IKKβ inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α production in a steroid-insensitive in vitro model of oxidative stress.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Citation for PF 184
The citations listed below are publications that use Tocris products. Selected citations for PF 184 include:
1 Citation: Showing 1 - 1
Bindarit: an anti-inflammatory small molecule that modulates the NFκB pathway.
Authors: Mora Et al.
Cell Cycle 2012;11:159
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RAW macrophages were incubated with 1 μM PF 184 for 30 min prior to addition of 200 ng/ml LPS for 8 h to follow TNFa mRNA expression. LPS elevated TNFa mRNA levels that was significantly inhibited by pretreatment of cells with PF 184.