Catalog Number: 4238
Chemical Name: 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide
Biological Activity
Potent and selective IKKβ inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α production in a steroid-insensitive in vitro model of oxidative stress.
Technical Data
  • M.Wt:
    619.09
  • Formula:
    C32H32ClFN6O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1187460-81-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Novel tight-binding inhibitory factor-κB kinase (IKK-2) inhibitors demostrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation.
    Sommers et al.
    J.Pharmacol.Exp.Ther., 2009;330:377
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PF 184 include:

1 Citations: Showing 1 - 1

  1. Bindarit: an anti-inflammatory small molecule that modulates the NFκB pathway.
    Authors: Mora Et al.
    Cell Cycle 2012;11:159

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