PF 429242 dihydrochloride

Catalog # Availability Size / Price Qty
3354/10
3354/50
PF 429242 dihydrochloride | CAS No. 2248666-66-0 | SREBP Inhibitors
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Description: Competitive inhibitor of SREBP site 1 protease

Chemical Name: 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide dihydrochloride

Purity: ≥97%

Product Details
Citations (5)
Reviews

Biological Activity

Reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). Selective for site 1 protease against a panel of serine proteases. Inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 μM). Also displays antiviral activity. Cell permeable.

Technical Data

M.Wt:
482.49
Formula:
C25H35N3O2.2HCl
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
≥97%
Storage:
Desiccate at RT
CAS No:
2248666-66-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for PF 429242 dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PF 429242 dihydrochloride include:

5 Citations: Showing 1 - 5

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