PF 4708671

Catalog # Availability Size / Price Qty
4032/25
4032/5
RSK Inhibitors Small Molecule
1 Image
Description: S6K1 inhibitor

Chemical Name: 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole

Purity: ≥98%

Product Details
Citations (9)
Reviews

Biological Activity

Cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki = 20 nM; IC50 = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo. Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro.

Technical Data

M.Wt:
390.41
Formula:
C19H21F3N6
Solubility:
Soluble to 50 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1255517-76-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for PF 4708671

The citations listed below are publications that use Tocris products. Selected citations for PF 4708671 include:

9 Citations: Showing 1 - 9

  1. The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development.
    Authors: Xing Et al.
    Front Cell Dev Biol  2018;6:134
  2. Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways.
    Authors: Pirbhoy Et al.
    Learn Mem  2017;24:341
  3. Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.
    Authors: Sinha Et al.
    Autophagy  2017;13:169
  4. Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation.
    Authors: Salmond Et al.
    J Immunol  2015;195:4615
  5. Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.
    Authors: Hullinger Et al.
    Neurobiol Learn Mem  2015;125:126
  6. Regulation of cardiac expression of the diabetic marker microRNA miR-29.
    Authors: Arnold Et al.
    PLoS One  2014;9:e103284
  7. Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer.
    Authors: Al-Ejeh Et al.
    Tuberc Respir Dis (Seoul)  2014;5:3145
  8. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.
    Authors: Melemedjian Et al.
    Pain  2013;154:1080
  9. Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory response.
    Authors: Wang Et al.
    J Immunol  2011;186:5217

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