Chemical Name: 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole
Biological ActivityPF 4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki = 20 nM; IC50 = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo. Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterisation of PF-4708671 a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).
Pearce et al.
Citations for PF 4708671
The citations listed below are publications that use Tocris products. Selected citations for PF 4708671 include:
9 Citations: Showing 1 - 9
The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development.
Authors: Xing Et al.
Front Cell Dev Biol 2018;6:134
Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways.
Authors: Pirbhoy Et al.
Learn Mem 2017;24:341
Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cells.
Authors: Sinha Et al.
Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation.
Authors: Salmond Et al.
J Immunol 2015;195:4615
Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.
Authors: Hullinger Et al.
Neurobiol Learn Mem 2015;125:126
Regulation of cardiac expression of the diabetic marker microRNA miR-29.
Authors: Arnold Et al.
PLoS One 2014;9:e103284
Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer.
Authors: Al-Ejeh Et al.
Tuberc Respir Dis (Seoul) 2014;5:3145
mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.
Authors: Melemedjian Et al.
Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory response.
Authors: Wang Et al.
J Immunol 2011;186:5217
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