PF 4708671

  (5 citations)   
Catalog Number:4032
Chemical Name:2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole
Product Details
Citations (5)
Reviews
Biological Activity
Cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) (Ki = 20 nM; IC50 = 160 nM). Suppresses the S6K1-mediated phosphorylation of S6, Rictor and mTOR in response to IGF1; displays no effect on the activity of RSK and MSK in vivo. Exhibits no significant inhibition of S6K2 or other AGC kinases (e.g. Akt, PKA and ROCK) in vitro.
Technical Data
  • M.Wt:
    390.41
  • Formula:
    C19H21F3N6
  • Solubility:
    Soluble to 50 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    1255517-76-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PF 4708671 include:

5 Citations: Showing 1 - 5
Filter your results:

  1. Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation.
    Authors: Salmond Et al.
    J Immunol  2015;195:4615
  2. Regulation of cardiac expression of the diabetic marker microRNA miR-29.
    Authors: Arnold Et al.
    PLoS One  2014;9:e103284
  3. Kinome profiling reveals breast cancer heterogeneity and identifies targeted therapeutic opportunities for triple negative breast cancer.
    Authors: Al-Ejeh Et al.
    Tuberc Respir Dis (Seoul)  2014;5:3145
  4. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.
    Authors: Melemedjian Et al.
    Pain  2013;154:1080
  5. Convergence of the mammalian target of rapamycin complex 1- and glycogen synthase kinase 3-β-signaling pathways regulates the innate inflammatory response.
    Authors: Wang Et al.
    J Immunol  2011;186:5217

Have you used PF 4708671?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Information

reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: