PF 543 hydrochloride

Catalog # Availability Size / Price Qty
5754/10
5754/50
Cat.No. 5754 - PF 543 hydrochloride | C27H31NO4S.HCl | CAS No. 1706522-79-3
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Description: Potent and selective SphK1 inhibitor

Chemical Name: (2R)-1-[[(4-[[3-Methyl-5-[(phenylsulfonyl)methyl]phenoxy]methyl]phenyl]methyl]-2-pyrrolidinemethanol hydrochloride

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective SphK1 inhibitor (IC50 = 2 nM; Ki = 3.6 nM). Exhibits >100-fold selectivity for Sphk1 over Sphk2. Also exhibits >5,000 fold selectivity over S1P1-5 receptors and 48 protein and lipid kinases. Attenuates proliferation and induces necrosis in human colorectal cancer cells in vitro. Suppresses HCT-116 tumor xenograft growth in mice.

Technical Data

M.Wt:
502.07
Formula:
C27H31NO4S.HCl
Solubility:
Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1706522-79-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

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