Catalog Number: 3316
Chemical Name: 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride
Biological Activity
Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. An inhibitor of casein kinase Iε induces phase delays in circadian rhythms under free-running and entrained conditions.
    Badura et al.
    J.Pharmacol.Exp.Ther., 2007;322:730
  2. A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine.
    Bryant et al.
    Psychopharmacology, 2009;203:703
  3. Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys.
    Sprose et al.
    Psychopharmacology, 2009;204:735
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