Potent and selective casein kinase 1ε
) and CK1δ
values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50
= 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo
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An inhibitor of casein kinase Iε induces phase delays in circadian rhythms under free-running and entrained conditions.
Badura et al.
A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine.
Bryant et al.
Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys.
Sprose et al.
The citations listed below are publications that use Tocris products. Selected citations for PF 670462 include:
Showing Results 1 - 7 of 7