PF 670462

Catalog # Availability Size / Price Qty
3316/10
3316/50
PF 670462 | CAS No. 950912-80-8 | Casein Kinase 1 Inhibitors
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Description: Potent and selective CK1ε and CK1δ inhibitor

Chemical Name: 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride

Purity: ≥99%

Product Details
Citations (11)
Reviews

Biological Activity

Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.

Technical Data

M.Wt:
410.32
Formula:
C19H20FN5.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
950912-80-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PF 670462

The citations listed below are publications that use Tocris products. Selected citations for PF 670462 include:

11 Citations: Showing 1 - 10

  1. Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis.
    Authors: Zhang Et al.
    Oncogene  2018;37:363
  2. Application of Integrated Drug Screening/Kinome Analysis to Identify Inhibitors of dFdCyd-Resistant Pancreatic Cancer Cell Growth.
    Authors: Krulikas Et al.
    SLAS Discov  2018;23:850
  3. Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1.
    Authors: Greer Et al.
    PLoS One  2017;12:e0170903
  4. Metabolic cycles in yeast share features conserved among circadian rhythms.
    Authors: Causton Et al.
    Curr.Biol.  2015;25:1056
  5. Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway.
    Authors: Kaucka Et al.
    Cell Commun Signal  2015;13:2
  6. Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.
    Authors: Cheong Et al.
    J Clin Invest  2015;125:1401
  7. CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.
    Authors: Zemp Et al.
    J Cell Sci  2014;127:1242
  8. Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.
    Authors: Kurihara Et al.
    Mol Pain  2014;10:17
  9. Circadian and circalunar clock interactions in a marine annelid.
    Authors: Zantke Et al.
    PLoS One  2013;5:99
  10. Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra.
    Authors: Zhang Et al.
    Curr Biol  2013;23:1863

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