PH 797804

Catalog # Availability Size / Price Qty
5866/10
5866/50
Cat.No. 5866 - PH 797804 | C22H19BrF2N2O3 | CAS No. 1358027-80-1
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Description: Potent and selective p38α/β inhibitor

Chemical Name: (-)-3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

Potent and selective p38α/β inhibitor (IC50 values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38α/β over 71 other kinases, enzymes and GPCRs, including p38γ, p38δ, JNK and ERK2. Inhibits LPS-induced TNFα production in U937 monocytes in vitro. Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active.

PH 797804 is the (-)-atropisomer, which is 100-fold more potent than its (+)-atropisomer.

Technical Data

M.Wt:
477.3
Formula:
C22H19BrF2N2O3
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1358027-80-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc
Other Product-Specific Information:
  • PH 797804 is the (-)-atropisomer, which is 100-fold more potent than its (+)-atropisomer

Product Datasheets

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