Catalog Number: 5866
Chemical Name: (-)-3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide
Biological Activity
Potent and selective p38α/β inhibitor (IC50 values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38α/β over 71 other kinases, enzymes and GPCRs, including p38γ, p38δ, JNK and ERK2. Inhibits LPS-induced TNFα production in U937 monocytes in vitro. Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active.

PH 797804 is the (-)-atropisomer, which is 100-fold more potent than its (+)-atropisomer.

Technical Data
  • M.Wt:
    477.3
  • Formula:
    C22H19BrF2N2O3
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1358027-80-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc
Other Product-Specific Information:
  • PH 797804 is the (-)-atropisomer, which is 100-fold more potent than its (+)-atropisomer
Background References
  1. Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation.
    Hope et al.
    J.Pharmacol.Exp.Ther., 2009;331:882
  2. Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase.
    Selness et al.
    Bioorg.Med.Chem.Lett., 2011;21:4066

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