Agonist of the α
7 nicotinic acetylcholine receptor (Ki
values are 44 and 2800 for α
7 and 5-HT3
values are > 100 μ
M for α
4 and α
respectively, and % inhibition is < 1 and 5% for α
2 and hERG respectively). Orally active and brain penetrant.
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Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists.
Walker et al.
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