hh PHA 568487 (CAS 527680-57-5): R&D Systems
Catalog Number: 3134
Chemical Name: N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-1,4-benzodioxin-6-carboxamide fumarate
Biological Activity
Agonist of the α7 nicotinic acetylcholine receptor (Ki values are 44 and 2800 for α7 and 5-HT3 respectively, IC50 values are > 100 μM for α3β4 and α1β1δγ respectively, and % inhibition is < 1 and 5% for α4β2 and hERG respectively). Orally active and brain penetrant.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists.
    Walker et al.
    Bioorg.Med.Chem., 2006;14:8219

The citations listed below are publications that use Tocris products. Selected citations for PHA 568487 include:

2 Citations: Showing 1 - 2
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  1. Neuroprotective effect of the alpha 7 nicotinic receptor agonist PHA 543613 in an n vivo excitotoxic adult rat model.
    Authors: Foucault-Fruchard
    Neuroscience 2017;356:52
  2. Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome.
    Authors: Su Et al.
    Mol Med 2013;18:1481

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