PHA 767491 hydrochloride

  ( 4 citations )    
Product Datasheet
Catalog Number:3140
Chemical Name:1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride
Product Details
Citations (4)
Reviews
Biological Activity
Potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines (IC50 ~ 0.86 - 5.87 μM) and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2) (IC50 = 171 nM).
Technical Data
  • M.Wt:
    249.7
  • Formula:
    C12H11N3O.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    942425-68-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PHA 767491 hydrochloride include:

4 Citations: Showing 1 - 4
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  1. DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach.
    Authors: Wu Et al.
    Nucleic Acids Res  2016;44:8786
  2. Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP.
    Authors: Bartley Et al.
    Eneuro  2016;3
  3. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response.
    Authors: FitzGerald Et al.
    PLoS One  2014;9:e98891
  4. Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells.
    Authors: Gardner Et al.
    Breast Cancer Res  2011;13:R53

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