Potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50
values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines (IC50
~ 0.86 - 5.87 μ
M) and induces apoptosis in a p53-independent manner in vivo
. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK2) (IC50
= 171 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).
Anderson et al.
Stopping replication, at the beginning.
Nature Chem.Biol., 2008;4:331
The citations listed below are publications that use Tocris products. Selected citations for PHA 767491 hydrochloride include:
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