Catalog Number: 4326
Chemical Name: 9-Ethyl-N-methyl-9H-carbazole-3-methanamine hydrochloride
Biological Activity
p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological reactivation of mutant p53: from protein structure to the cancer patient.
    Oncogene., 2010;29:4245
  2. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.
    Boeckler et al.
    Proc.Natl.Acad.Sci., 2008;105:10360
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