Chemical Name: 9-Ethyl-N-methyl-9H-carbazole-3-methanamine hydrochloride
Biological ActivityPhiKan 083 is a p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Slows rate of thermal denaturation of p53-Y220C.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug.
Boeckler et al.
Pharmacological reactivation of mutant p53: from protein structure to the cancer patient.
Citation for PhiKan 083
The citations listed below are publications that use Tocris products. Selected citations for PhiKan 083 include:
1 Citation: Showing 1 - 1
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule.
Authors: Soares Et al.
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