Philanthotoxin 74

Catalog # Availability Size / Price Qty
2770/1
2770/10
2770/50
Philanthotoxin 74 | CAS No. 1227301-51-0 | AMPA Receptor Antagonists
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Description: GluA1 and GluA3 selective AMPA antagonist
Alternative Names: PhTx-74

Chemical Name: (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride

Purity: ≥98%

Product Details
Citations (2)
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Reviews

Biological Activity

AMPA receptor antagonist. Non-selective homomeric GluA3 and GluA1 receptor antagonist (IC50 values are 263 and 296 nM respectively). Inhibits homomeric GluA3 and GluA1 with a 100-fold greater potency than heteromeric GluA1/2 and GluA2/3 receptors.

Technical Data

M.Wt:
507.54
Formula:
C24H42N4O3.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1227301-51-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors.
    Poulsen et al.
    Mol.Pharmacol., 2013;85:261
  2. A subtype-selective, use-dependent inhibitor of native AMPA receptors.
    Nilsen and England
    J.Am.Chem.Soc., 2007;129:4902

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Citations for Philanthotoxin 74

The citations listed below are publications that use Tocris products. Selected citations for Philanthotoxin 74 include:

2 Citations: Showing 1 - 2

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