AMPA receptor antagonist. Non-selective homomeric GluR3 and GluR1 receptor antagonist (IC50
values are 263 and 296 nM respectively). Inhibits homomeric GluR3 and GluR1 with a 100-fold greater potency than heteromeric GluR1/2 and GluR2/3 receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A subtype-selective, use-dependent inhibitor of native AMPA receptors.
Nilsen and England
Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors.
Poulsen et al.
The citations listed below are publications that use Tocris products. Selected citations for Philanthotoxin 74 include:
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