Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diyl butanoic acid ester
Biological ActivityPhorbol 12,13-dibutyrate is a protein kinase C activator. Induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Activity does not alter intracellular Ca2+ concentration. Also inhibits the activity of Na+,K+ ATPase in OK cells.
For more information about how Phorbol 12,13-dibutyrate may be used, see our protocol: Generation of β cells from hPSCs
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells.
Middleton et al.
Presynaptic mechanism for phorphol ester-induced synaptic potentiation.
Hori et al.
Augmented PDBu-mediated contaction of bronchial smooth muscle of mice with antigen-induced airway hyperresponsiveness.
Sakai et al.
J.Smooth Muscle Res., 2010;46:259
Citations for Phorbol 12,13-dibutyrate
The citations listed below are publications that use Tocris products. Selected citations for Phorbol 12,13-dibutyrate include:
3 Citations: Showing 1 - 3
Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.
Authors: Nieuwenhuijze Et al.
Front Immunol 2018;9:2234
Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.
Authors: Nostro Et al.
J Cell Biol 2015;4:591
Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors.
Authors: Sánchez Et al.
Br J Pharmacol 2014;171:5682
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