Phorbol 12,13-dibutyrate

Catalog # Availability Size / Price Qty
4153/1
Phorbol 12,13-dibutyrate | CAS No. 37558-16-0 | Protein Kinase C Activators
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Description: Protein kinase C activator
Alternative Names: PDBu

Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diyl butanoic acid ester

Purity: ≥97%

Product Details
Citations (3)
Reviews

Biological Activity

Phorbol 12,13-dibutyrate is a protein kinase C activator. Induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Activity does not alter intracellular Ca2+ concentration. Also inhibits the activity of Na+,K+ ATPase in OK cells.

For more information about how Phorbol 12,13-dibutyrate may be used, see our protocol: Generation of β cells from hPSCs

Technical Data

M.Wt:
504.61
Formula:
C28H40O8
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
37558-16-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Phorbol 12,13-dibutyrate

The citations listed below are publications that use Tocris products. Selected citations for Phorbol 12,13-dibutyrate include:

3 Citations: Showing 1 - 3

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