Phorbol 12,13-dibutyrate

Catalog # Availability Size / Price Qty
4153/1
Protein Kinase C Activators Small Molecule
1 Image
Description: Protein kinase C activator
Alternative Names: PDBu

Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diyl butanoic acid ester

Purity: ≥98%

Product Details
Citations (3)
Reviews (1)

Biological Activity

Protein kinase C activator. Induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Activity does not alter intracellular Ca2+ concentration. Also inhibits the activity of Na+,K+ ATPase in OK cells.

Technical Data

M.Wt:
504.61
Formula:
C28H40O8
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
37558-16-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Phorbol 12,13-dibutyrate

The citations listed below are publications that use Tocris products. Selected citations for Phorbol 12,13-dibutyrate include:

3 Citations: Showing 1 - 3

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PDB reduces saxagliptin-induced APD prolongation in cardiomyocytes
By Chintan Koyani on 10/22/2018
Species: Other

Guinea pig ventricular cardiomyocytes were patched and superfused with Saxagliptin (2 µM, 5 min) followed by Phorbol 12,13-dibutyrate (PDB, 10 nM, 5 min) and action potentials were stimulated at a 1 Hz frequency. Action potential duration (APD) were analysed at 20%, 50% and 90% repolarization (shown in Image). PDB reduced saxagliptin-induced APD prolongation.


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