Home / Protein Kinase C Activators / Phorbol 12,13-dibutyrate

Phorbol 12,13-dibutyrate

4153 3 Citations 1 Review Datasheet / COA / SDS
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4153/1
Phorbol 12,13-dibutyrate | CAS No. 37558-16-0 | Protein Kinase C Activators
1 Image
Description: Protein kinase C activator
Alternative Names: PDBu

Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diyl butanoic acid ester

Purity: ≥98%

Product Details
Citations (3)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Phorbol 12,13-dibutyrate is a protein kinase C activator. Induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Activity does not alter intracellular Ca2+ concentration. Also inhibits the activity of Na+,K+ ATPase in OK cells.

Technical Data

M.Wt:
504.61
Formula:
C28H40O8
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
37558-16-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Phorbol 12,13-dibutyrate

The citations listed below are publications that use Tocris products. Selected citations for Phorbol 12,13-dibutyrate include:

3 Citations: Showing 1 - 3

  1. Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.
    Authors: Nieuwenhuijze Et al.
    Front Immunol  2018;9:2234
  2. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.
    Authors: Nostro Et al.
    J Cell Biol  2015;4:591
  3. Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors.
    Authors: Sánchez Et al.
    Br J Pharmacol  2014;171:5682

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PDB reduces saxagliptin-induced APD prolongation in cardiomyocytes
By Chintan Koyani on 10/22/2018
Application: Species: Other

Guinea pig ventricular cardiomyocytes were patched and superfused with Saxagliptin (2 µM, 5 min) followed by Phorbol 12,13-dibutyrate (PDB, 10 nM, 5 min) and action potentials were stimulated at a 1 Hz frequency. Action potential duration (APD) were analysed at 20%, 50% and 90% repolarization (shown in Image). PDB reduced saxagliptin-induced APD prolongation.

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