Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diyl butanoic acid ester
Biological ActivityPhorbol 12,13-dibutyrate is a protein kinase C activator. Induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Activity does not alter intracellular Ca2+ concentration. Also inhibits the activity of Na+,K+ ATPase in OK cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells.
Middleton et al.
Presynaptic mechanism for phorphol ester-induced synaptic potentiation.
Hori et al.
Augmented PDBu-mediated contaction of bronchial smooth muscle of mice with antigen-induced airway hyperresponsiveness.
Sakai et al.
J.Smooth Muscle Res., 2010;46:259
Citations for Phorbol 12,13-dibutyrate
The citations listed below are publications that use Tocris products. Selected citations for Phorbol 12,13-dibutyrate include:
3 Citations: Showing 1 - 3
Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.
Authors: Nieuwenhuijze Et al.
Front Immunol 2018;9:2234
Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.
Authors: Nostro Et al.
J Cell Biol 2015;4:591
Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors.
Authors: Sánchez Et al.
Br J Pharmacol 2014;171:5682
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Guinea pig ventricular cardiomyocytes were patched and superfused with Saxagliptin (2 µM, 5 min) followed by Phorbol 12,13-dibutyrate (PDB, 10 nM, 5 min) and action potentials were stimulated at a 1 Hz frequency. Action potential duration (APD) were analysed at 20%, 50% and 90% repolarization (shown in Image). PDB reduced saxagliptin-induced APD prolongation.