Home / Protein Kinase C Activators / Phorbol 12,13-dibutyrate

Phorbol 12,13-dibutyrate

4153 3 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4153/1
Phorbol 12,13-dibutyrate | CAS No. 37558-16-0 | Protein Kinase C Activators
1 Image
Description: Protein kinase C activator
Alternative Names: PDBu

Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diyl butanoic acid ester

Purity: ≥98%

Product Details
Citations (3)
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Protein kinase C activator. Induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Activity does not alter intracellular Ca2+ concentration. Also inhibits the activity of Na+,K+ ATPase in OK cells.

Technical Data

M.Wt:
504.61
Formula:
C28H40O8
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
37558-16-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Phorbol 12,13-dibutyrate

The citations listed below are publications that use Tocris products. Selected citations for Phorbol 12,13-dibutyrate include:

3 Citations: Showing 1 - 3

  1. Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.
    Authors: Nieuwenhuijze Et al.
    Front Immunol  2018;9:2234
  2. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.
    Authors: Nostro Et al.
    J Cell Biol  2015;4:591
  3. Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors.
    Authors: Sánchez Et al.
    Br J Pharmacol  2014;171:5682

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Phorbol 12,13-dibutyrate

Average Rating: 5 (Based on 1 Review)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Phorbol 12,13-dibutyrate?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


PDB reduces saxagliptin-induced APD prolongation in cardiomyocytes
By Chintan Koyani on 10/22/2018
Application: Species: Other

Guinea pig ventricular cardiomyocytes were patched and superfused with Saxagliptin (2 µM, 5 min) followed by Phorbol 12,13-dibutyrate (PDB, 10 nM, 5 min) and action potentials were stimulated at a 1 Hz frequency. Action potential duration (APD) were analysed at 20%, 50% and 90% repolarization (shown in Image). PDB reduced saxagliptin-induced APD prolongation.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.