Catalog Number: 4153
Alternate Names: PDBu
Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diyl butanoic acid ester
Biological Activity
Protein kinase C activator. Induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Activity does not alter intracellular Ca2+ concentration. Also inhibits the activity of Na+,K+ ATPase in OK cells.
Technical Data
  • M.Wt:
    504.61
  • Formula:
    C28H40O8
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    37558-16-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells.
    Middleton et al.
    J.Biol.Chem., 1993;268:15958
  2. Presynaptic mechanism for phorphol ester-induced synaptic potentiation.
    Hori et al.
    J.Neurosci., 1999;19:7262
  3. Augmented PDBu-mediated contaction of bronchial smooth muscle of mice with antigen-induced airway hyperresponsiveness.
    Sakai et al.
    J.Smooth Muscle Res., 2010;46:259
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Phorbol 12,13-dibutyrate include:

1 Citations: Showing 1 - 1

  1. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines.
    Authors: Nostro Et al.
    J Cell Biol 2015;4:591

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