PI 103 hydrochloride
Chemical Name: 3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride
Biological ActivityPI 103 hydrochloride is an inhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR (IC50 values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110α, mTORC1, PI 3-KC2β, p110δ, mTORC2, p110β, p110γ, ATR, ATM, PI 3-KC2α and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo. Induces autophagosome formation in glioma cells.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
A pharmacological map of the PI3-K family defines a role for p110α in Ins signaling.
Knight et al.
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
Fan et al.
Cancer cell, 2006;9:341
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositol 3-kinase.
Raynaud et al.
Cancer Res., 2007;67:5840
Akt and autophagy cooperate to promote survival of drug-resistant glioma.
Fan et al.
Citations for PI 103 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for PI 103 hydrochloride include:
10 Citations: Showing 1 - 10
Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.
Authors: Genga Et al.
Cell Rep 2019;27:708
Capacitation of human na�ve pluripotent stem cells for multi-lineage differentiation.
Authors: Rostovskaya Et al.
Epigenetic resetting of human pluripotency.
Authors: Guo Et al.
Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.
Authors: Li Et al.
J Exp Med 2014;9:e104809
Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
Authors: Brown Et al.
PLoS One 2014;88:13149
OE and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.
Authors: Li Et al.
P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments.
Authors: Campbell Et al.
PLoS One 2013;8:e53982
ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
Authors: Montané and Menand
J Virol 2013;64:4361
Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta.
Authors: Peng Et al.
PLoS One 2012;7:e47572
A screen for regulators of survival of motor neuron protein levels.
Authors: Makhortova Et al.
Nat Chem Biol 2011;7:544
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for PI 103 hydrochloride
There are currently no reviews for this product. Be the first to review PI 103 hydrochloride and earn rewards!
Have you used PI 103 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image