Inhibitor of DNA-PK, PI 3-kinase (p110α
) and mTOR (IC50
values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110α
, mTORC1, PI 3-KC2β
, mTORC2, p110β
, ATR, ATM, PI 3-KC2α
and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo
. Induces autophagosome formation in glioma cells.
Soluble to 20 mM in DMSO
Desiccate at +4°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
Fan et al.
Cancer cell, 2006;9:341
A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling.
Knight et al.
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositol 3-kinase.
Raynaud et al.
Cancer Res., 2007;67:5840
Akt and autophagy cooperate to promote survival of drug-resistant glioma.
Fan et al.
The citations listed below are publications that use Tocris products. Selected citations for PI 103 hydrochloride include:
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