PI 103 hydrochloride

Catalog # Availability Size / Price Qty
PI 103 hydrochloride | CAS No. 371935-79-4 | PI 3-Kinase Inhibitors
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Description: Inhibitor of PI 3-kinase, mTOR and DNA-PK

Chemical Name: 3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride

Purity: ≥98%

Product Details
Citations (10)

Biological Activity

PI 103 hydrochloride is an inhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR (IC50 values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110α, mTORC1, PI 3-KC2β, p110δ, mTORC2, p110β, p110γ, ATR, ATM, PI 3-KC2α and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo. Induces autophagosome formation in glioma cells.

Technical Data

Soluble to 20 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PI 103 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PI 103 hydrochloride include:

10 Citations: Showing 1 - 10

  1. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.
    Authors: Genga Et al.
    Cell Rep  2019;27:708
  2. Capacitation of human na�ve pluripotent stem cells for multi-lineage differentiation.
    Authors: Rostovskaya Et al.
    Development  2019;146
  3. Epigenetic resetting of human pluripotency.
    Authors: Guo Et al.
    Development  2017;144:2748
  4. Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.
    Authors: Li Et al.
    J Exp Med  2014;9:e104809
  5. Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
    Authors: Brown Et al.
    PLoS One  2014;88:13149
  6. OE and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.
    Authors: Li Et al.
    Pain  2014;211:15
  7. P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments.
    Authors: Campbell Et al.
    PLoS One  2013;8:e53982
  8. ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
    Authors: Montané and Menand
    J Virol  2013;64:4361
  9. Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta.
    Authors: Peng Et al.
    PLoS One  2012;7:e47572
  10. A screen for regulators of survival of motor neuron protein levels.
    Authors: Makhortova Et al.
    Nat Chem Biol  2011;7:544


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