PI 103 hydrochloride
Chemical Name: 3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride
Biological ActivityInhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR (IC50 values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110α, mTORC1, PI 3-KC2β, p110δ, mTORC2, p110β, p110γ, ATR, ATM, PI 3-KC2α and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo. Induces autophagosome formation in glioma cells.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A pharmacological map of the PI3-K family defines a role for p110α in Ins signaling.
Knight et al.
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
Fan et al.
Cancer cell, 2006;9:341
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositol 3-kinase.
Raynaud et al.
Cancer Res., 2007;67:5840
Akt and autophagy cooperate to promote survival of drug-resistant glioma.
Fan et al.
Citations for PI 103 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for PI 103 hydrochloride include:
10 Citations: Showing 1 - 10
Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development.
Authors: Genga Et al.
Cell Rep 2019;27:708
Capacitation of human na�ve pluripotent stem cells for multi-lineage differentiation.
Authors: Rostovskaya Et al.
Epigenetic resetting of human pluripotency.
Authors: Guo Et al.
Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.
Authors: Li Et al.
J Exp Med 2014;9:e104809
Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis.
Authors: Brown Et al.
PLoS One 2014;88:13149
OE and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.
Authors: Li Et al.
P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments.
Authors: Campbell Et al.
PLoS One 2013;8:e53982
ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change.
Authors: Montané and Menand
J Virol 2013;64:4361
Platelet-derived growth factor CC-mediated neuroprotection against HIV Tat involves TRPC-mediated inactivation of GSK 3beta.
Authors: Peng Et al.
PLoS One 2012;7:e47572
A screen for regulators of survival of motor neuron protein levels.
Authors: Makhortova Et al.
Nat Chem Biol 2011;7:544
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