Catalog Number: 2930
Chemical Name: 3-[4-(4-Morpholinylpyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol hydrochloride
Biological Activity
Inhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR (IC50 values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110α, mTORC1, PI 3-KC2β, p110δ, mTORC2, p110β, p110γ, ATR, ATM, PI 3-KC2α and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo. Induces autophagosome formation in glioma cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 20 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.
    Fan et al.
    Cancer cell, 2006;9:341
  2. A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling.
    Knight et al.
    Cell, 2006;125:733
  3. Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositol 3-kinase.
    Raynaud et al.
    Cancer Res., 2007;67:5840
  4. Akt and autophagy cooperate to promote survival of drug-resistant glioma.
    Fan et al.
    Sci.Signal., 2010;3:ra81
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