PI 103 hydrochloride

Key Product Details

Product Description

PI 103 hydrochloride is an inhibitor of DNA-PK, PI 3-kinase (p110α) and mTOR (IC₅₀ values are 2, 8, 20, 26, 48, 83, 88, 150, 850, 920, ~ 1000 and 2300 nM for DNA-PK, p110α, mTORC1, PI 3-KC2β, p110δ, mTORC2, p110β, p110γ, ATR, ATM, PI 3-KC2α and hsVPS34 respectively). Inhibits growth of human tumor xenografts in mice in vivo. Induces autophagosome formation in glioma cells.

Product Specifications for PI 103 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PI 103 hydrochloride

The following data is based on the product molecular weight 384.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	12.99 mL	64.97 mL	129.93 mL
1 mM	2.60 mL	12.99 mL	25.99 mL
2 mM	1.30 mL	6.50 mL	12.99 mL
10 mM	0.26 mL	1.30 mL	2.60 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 31 publications citing the usage of this product.

• Fan Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci.Signal. 2010 PMID: 21062993
• Knight A pharmacological map of the PI3-K family defines a role for p110α in Ins signaling. Cell 2006 PMID: 16647110
• Raynaud Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositol 3-kinase. Cancer Res. 2007 PMID: 17575152
• Fan A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer cell 2006 PMID: 16697955

Product Documents for PI 103 hydrochloride