Picropodophyllotoxin

Key Product Details

Product Description

Picropodophyllotoxin is an orally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC₅₀ ~ 1 nM), increases the fraction of cells in the G₂/M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC₅₀ = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.

Product Specifications for Picropodophyllotoxin

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Picropodophyllotoxin

The following data is based on the product molecular weight 414.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.07 mL	24.13 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 22 publications citing the usage of this product.

• Stromberg IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G₂/M-phase accumulation and apoptosis in multiple myeloma cells. Blood 2006 PMID: 16166596
• Economou Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the Ins-like growth factor-1 receptor. Invest.Ophthalmol.Vis.Sci. 2008 PMID: 18515591
• Girnita Cyclolignans as inhibitors of the Ins-like growth factor-1 receptor and malignant cell growth. Cancer Res. 2004 PMID: 14729630

Product Documents for Picropodophyllotoxin