Pifithrin-α hydrobromide

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1267/10
1267/50
Pifithrin-α hydrobromide | CAS No. 63208-82-2 | p53 Inhibitors
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Description: p53 inhibitor. Also aryl hydrocarbon receptor agonist

Chemical Name: 1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide

Product Details
Citations (4)
Reviews (1)

Biological Activity

Inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of cancer therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM). Cyclic analog available (Cat. No. 3843).

Technical Data

M.Wt:
367.3
Formula:
C16H18N2OS.HBr
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
63208-82-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Pifithrin-α hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for Pifithrin-α hydrobromide include:

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The effect of p53 loss in human lung cancer cell lines.
By Anonymous on 01/04/2018
Species: Human

We used the p53 inhibitor in order to tackle the p53 protein in-vitro for some cellular proliferation assays,


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