Catalog Number: 1093
Chemical Name: 5-methyl-1-phenyl-2(1H)-pyridinone
Biological Activity
Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.
Technical Data
  • M.Wt:
    185.23
  • Formula:
    C12H11NO
  • Solubility:
    Soluble to 20 mM in water
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    53179-13-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice.
    Kehrer and Margolin
    Toxicol.Lett., 1997;90:125
  2. Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.
    Iyer et al.
    J.Pharmacol.Exp.Ther., 1999;289:211
  3. Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats.
    Mei et al.
    J.Pharmacol.Exp.Ther., 2005;313:379
  4. Pirfenidone suppresses tumor necrosis factor-α, enhances interleukin-10 and protects mice from endotoxic shock.
    Oku et al.
    Eur.J.Pharmacol., 2002;446:167

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