Pirfenidone

Key Product Details

Product Description

Pirfenidone is a antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.

Product Specifications for Pirfenidone

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Pirfenidone

The following data is based on the product molecular weight 185.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

7 6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	26.99 mL	134.97 mL	269.93 mL
1 mM	5.40 mL	26.99 mL	53.99 mL
2 mM	2.70 mL	13.50 mL	26.99 mL
10 mM	0.54 mL	2.70 mL	5.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

• Oku Pirfenidone suppresses tumor necrosis factor-α, enhances interleukin-10 and protects mice from endotoxic shock. Eur.J.Pharmacol. 2002 PMID: 12098599
• Kehrer and Margolin Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice. Toxicol.Lett. 1997 PMID: 9067480
• Mei Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats. J.Pharmacol.Exp.Ther. 2005 PMID: 15608079
• Iyer Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleo. hamster model of lung fibrosis. J.Pharmacol.Exp.Ther. 1999 PMID: 10087006

Product Documents for Pirfenidone