Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo
. Potent scavenger of free radicals and inhibitor of lipid peroxidation.
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All Tocris products are intended for laboratory research use only.
Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice.
Kehrer and Margolin
Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleomycin hamster model of lung fibrosis.
Iyer et al.
Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats.
Mei et al.
Pirfenidone suppresses tumor necrosis factor-α, enhances interleukin-10 and protects mice from endotoxic shock.
Oku et al.