Chemical Name: 5-methyl-1-phenyl-2(1H)-pyridinone
Biological ActivityPirfenidone is a antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Protection of pirfenidone against an early phase of oleic acid-induced acute lung injury in rats.
Mei et al.
Pirfenidone diminishes cyclophosphamide-induced lung fibrosis in mice.
Kehrer and Margolin
Pirfenidone suppresses tumor necrosis factor-α, enhances interleukin-10 and protects mice from endotoxic shock.
Oku et al.
Effects of pirfenidone on procollagen gene expression at the transcriptional level in bleo. hamster model of lung fibrosis.
Iyer et al.
Citation for Pirfenidone
The citations listed below are publications that use Tocris products. Selected citations for Pirfenidone include:
1 Citation: Showing 1 - 1
Anti-fibrotic effects of CXCR4-targeting i-body AD-114 in preclinical models of pulmonary fibrosis.
Sci Rep 2018;8(1):3212
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