PKUMDL WQ 2201

Tocris Bioscience | Catalog # 6581

Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
Tocris Bioscience
Discontinued Product
6581 has been discontinued. View all Dehydrogenase Inhibitors products.

Key Product Details

Description

Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)
View all Dehydrogenase Inhibitors »

Product Description

PKUMDL WQ 2201 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.

Product Specifications for PKUMDL WQ 2201

Molecular Weight

351.81

Formula

C15H14ClN3O3S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid

CAS Number

592474-91-4

PubChem ID

5453153

InChI Key

XPACBFAEZIPDRT-LSCVHKIXSA-N

SMILES

CCNC(N/N=C/C1=CC=C(C2=CC(Cl)=C(C(O)=O)C=C2)O1)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.18 100

Preparing Stock Solutions for PKUMDL WQ 2201

The following data is based on the product molecular weight 351.81.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.84 mL 14.21 mL 28.42 mL
5 mM 0.57 mL 2.84 mL 5.68 mL
10 mM 0.28 mL 1.42 mL 2.84 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for PKUMDL WQ 2201

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PKUMDL WQ 2201

For research use only

Related Research Areas

Redox Enzymes

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