PKUMDL WQ 2201
Chemical Name: 2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid
Biological ActivityNegative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC50 = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity.
Wang et al.
Cell Chem.Biol., 2017;24:55
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