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Plitidepsin

Name: Plitidepsin
Brand: Tocris Bioscience
SKU: 7416
Price: 329 USD
Availability: InStock

Tocris Bioscience | Catalog # 7416

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Product Documents

Potent protein synthesis inhibitor

Technical Data
Reviews

Product Description
Product Specifications
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent protein synthesis inhibitor

Alternative Names

Dehydrodidemnin B,DDB

View all DNA, RNA and Protein Synthesis Inhibitors »

Product Description

Plitidepsin (dehydrodidemnin B) is a potent inhibitor of protein synthesis, blocker of G1 and G2 phases in cell cycle and potent antiviral against SARS-CoV-2 in hACE2-293T, Vero E6 cells and models of pneumocyte-like cells (IC₉₀ values are 0.88 nM, 1.76 nM and 3.14 nM, respectively). Plitidepsin also inhibits eukaryotic translation elongation factor 1 alpha 1 (eEF1A) (K_D = 80 nM).

In vitro, it inhibits induction of ornithine decarboxylase (ODC), which is essential for cell transformation and proliferation.

In vivo, daily administration of Plitidepsin on mice affected by Ehrlich carcinoma duplicated the animal life-span and decreased the total number of tumor cells by 70-90%. Plitidepsin also reduces viral SARS-CoV-2 replication in the lungs (mouse).

It is recommended to prepare stock solutions in DMSO.

Product Specifications for Plitidepsin

Molecular Weight

1110.36

Formula

C₅₇H₈₇N₇O₁₅

Storage

Store at -20°C

Purity

≥98% (HPLC)

CAS Number

137219-37-5

PubChem ID

9812534

InChI Key

UUSZLLQJYRSZIS-LXNNNBEUSA-N

SMILES

[H][C@@]12CCCN1C([C@](CC(C)C)(NC([C@H](C([C@H](C(C)C)OC(C[C@@H]([C@](NC([C@H]([C@H](OC([C@@H](N(C2=O)C)CC3=CC=C(C=C3)OC)=O)C)NC([C@H](N(C([C@@H]4CCCN4C(C(C)=O)=O)=O)C)CC(C)C)=O)=O)([C@H](CC)C)[H])O)=O)=O)C)=O)[H])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product.

Reuschl Host-directed therapies against early-lineage SARS-CoV-2 retain efficacy against B.1.1.7 variant. bioRxiv 2021 PMID: 33501437
Losada Translation elongation factor eEF1A2 is a novel anticancer target for the marine natural product plitidepsin. Sci.Rep. 2016 PMID: 27713531
White Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A. Science 2021 PMID: 33495306
Urdiales Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates. Cancer Letters 1996 PMID: 8603376

Product Documents for Plitidepsin

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Plitidepsin

For research use only

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