(+)-Tubocurarine chloride

Tocris Bioscience | Catalog # 2820

nAChR antagonist
Tocris Bioscience

Key Product Details

Description

nAChR antagonist
View all Additional Nicotinic Receptor Antagonists »

Product Description

(+)-Tubocurarine chloride is a competitive, non-selective nicotinic acetylcholine receptor antagonist; causes skeletal muscle relaxation. Also a 5-HT3 and GABAA receptor antagonist.

Product Specifications for (+)-Tubocurarine chloride

Molecular Weight

681.65

Formula

C37H41ClN2O6.HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2,3,13a,14,15,16,25,25a,-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-13H-4,6:21,24-dietheno-8,12-metheno-1H-pyrido[3',2':14,15][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolinium chloride hydrochloride

CAS Number

57-94-3

PubChem ID

64645

InChI Key

GXFZCDMWGMFGFL-KKXMJGKMSA-N

SMILES

OC1=C(OC)C=C3C([C@@H]7[N+](C)(C)CC3)=C1OC(C=C5)=CC=C5C[C@H](N(C)CC4)C2=C4C=C(OC)C(OC6=C(O)C=CC(C7)=C6)=C2.[Cl-].Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 17.04 25

Preparing Stock Solutions for (+)-Tubocurarine chloride

The following data is based on the product molecular weight 681.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 5.87 mL 29.34 mL 58.68 mL
1.25 mM 1.17 mL 5.87 mL 11.74 mL
2.5 mM 0.59 mL 2.93 mL 5.87 mL
12.5 mM 0.12 mL 0.59 mL 1.17 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

  • Peters Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci.Letts.
  • Wotring and Yoon The inhibitory effects of nicotinic antagonists on currents elicited by GABA in rat hippocampal neurons. Neurosci.
  • Pederson and Cohen d-Tucocurarine binding sites are located at α-γ and α-δ subunit interfaces of the nicotinic acetylcholine receptor. Proc.Natl.Acad.Sci.USA

Product Documents for (+)-Tubocurarine chloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (+)-Tubocurarine chloride

For research use only

Citations for (+)-Tubocurarine chloride

Customer Reviews for (+)-Tubocurarine chloride (1)

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  • Neuromuscular blocking drugs
    Name: Anonymous
    Species: Chicken
    Assay Type: In Vivo
    Verified Customer | Posted 02/16/2018
    To emphasize its action mechanism is useful to compare it with 2 mg of Succinylcholine in a chicken model
    We use 2 mg of tubocurarine in a demonstration experiment to review its properties as a neuromuscular blocking drug
    (+)-Tubocurarine chloride 2820

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