PMSF

Catalog # Availability Size / Price Qty
4486/50
PMSF | CAS No. 329-98-6 | Additional Synthetic Protease Inhibitors
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Description: Non-selective protease inhibitor; also blocks anandamide metabolism

Chemical Name: Phenylmethylsulfonyl fluoride

Purity: ≥98%

Product Details
Reviews (1)

Biological Activity

Non-selective protease inhibitor; irreversibly sulfonates key active site serine residues in serine proteases, acetylcholinesterases, and thiol proteases. Blocks metabolism of anandamide (Cat. No. 1339) in a rodent model of cannabimimetic activity. Unstable in water (t1/2 ~ 60 mins at pH 7.5). Brain penetrant.

Technical Data

M.Wt:
174.19
Formula:
C7H7FO2S
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
329-98-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Works well for protein isolation
By Nicole Brown on 01/07/2019
Species: Mouse

Used to isolate protein from kidney tissue from wild type or IL-33 deficient mice that underwent cisplatin-induced kidney injury; several proteins were detected by immunoblot analysis; even after several freeze thaws, data has been consistent*additionally added a protease inhibitor cocktail and phosphatase inhibitor cocktail + RIPA for protein isolation

PMID: 29070568

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