Chemical Name: Phenylmethylsulfonyl fluoride
Biological ActivityPMSF is a non-selective protease inhibitor; irreversibly sulfonates key active site serine residues in serine proteases, acetylcholinesterases, and thiol proteases. Blocks metabolism of anandamide (Cat. No. 1339) in a rodent model of cannabimimetic activity. Unstable in water (t1/2 ~ 60 mins at pH 7.5). Brain penetrant.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The action of phenylmethylsulfonyl fluoride on human acetylcholinesterase, chymotrypsin and trypsin.
Turini et al.
The effect of the enzyme inhibitor phenylmethylsulfonyl fluoride on the pharmacological effect of anandamide in the mouse model of cannabimimetic activity.
Compton & Martin
Role of fatty acid amide hydrolase in the transport of the endogenous cannabinoid anandamide.
Day et al.
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