Endogenous cannabinoid and TRPV1 receptor agonist (K
values are 89 and 371 nM at CB
receptors respectively; EC
values are 18, 31 and 27 nM at GPR55, CB
= 5.68 for rTRPV1). Also blocks TNF-
B activation via direct inhibition of IKK.
water soluble emulsion. Deuterated analog also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products.
Selected citations for Anandamide include:
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The synthetic cannabinoid WIN-55,212-55,212 induced-apoptosis in cytotrophoblasts cells by a mechanism dependent on CB1 receptor.
AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids.
Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures.
Authors: Malek Et al.
Neural Plast 2015;2015:130639
The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation.
Authors: Smith Et al.
PLoS One 2015;10:e0136546
Mechanisms of endothelium-dependent relaxation evoked by anandamide in isolated human pulmonary arteries.
Authors: Baranowska-Kuczko Et al.
J Biomed Sci 2014;387:477
The inhibition of 2-arachidonoyl-glycerol (2-AG) biosynthesis, rather than enhancing striatal damage, protects striatal neurons from malonate-induced death: a potential role of cyclooxygenase-2-dependent metabolism of 2-AG.
Authors: Valdeolivas Et al.
Cell Death Dis 2013;4:e862
CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release.
Authors: Malenczyk Et al.
J Biol Chem 2013;288:32685
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Authors: Caiati Et al.
Sci Rep 2012;2:285
Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system.
Authors: Okine Et al.
Am J Physiol Heart Circ Physiol 2012;167:627
Capsaicin-induced changes in LTP in the lateral amygdala are mediated by TRPV1.
Authors: Zschenderlein Et al.
PLoS One 2011;6:e16116
Nigrostriatal denervation changes the effect of cannabinoids on subthalamic neuronal activity in rats.
Authors: Morera-Herreras Et al.
Psychopharmacology (Berl) 2011;214:379
Effects of TRPV1 activation on synaptic excitation in the dentate gyrus of a mouse model of temporal lobe epilepsy.
Authors: Bhaskaran and Smith
Cell Death Differ 2010;223:529
Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells.
Authors: Rajesh Et al.
Br J Pharmacol 2010;160:688
Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system.
Authors: Wang Et al.
Developmental expression of a functional TASK-1 2P domain K+ channel in embryonic chick heart.
Authors: Zhang Et al.
Br J Pharmacol 2009;16:104
Effect of the CB(1) receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices.
Authors: Mendiguren and Pineda
Br J Pharmacol 2009;158:1579
Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats.
Authors: Brozoski Et al.
Auton Neurosci 2009;150:82
Blockade of THC-seeking behavior and relapse in monkeys by the cannabinoid CB(1)-receptor antagonist rimonabant.
Authors: Justinova Et al.
TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 critically influence T lymphocyte effector functions.
Authors: Meuth Et al.
J Biol Chem 2008;283:14559
The differential contractile responses to capsaicin and anandamide in muscle strips isolated from the rat urinary bladder.
Authors: Saitoh Et al.
Br J Pharmacol 2007;570:182
TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning.
Authors: Cuypers Et al.
Exp Neurol 2007;361:214
Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase.
Authors: Bátkai Et al.
Am J Physiol Heart Circ Physiol 2007;293:H909
Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619.
Authors: Hillard Et al.
Br J Pharmacol 2007;152:691
Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol.
Authors: Ho and Randall
Naunyn Schmiedebergs Arch Pharmacol 2007;150:641
Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects.
Authors: Raduner Et al.
J Biol Chem 2006;281:14192
Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.
Authors: Bender Et al.
J Neurosci 2006;26:4166
Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase.
Authors: Pacher Et al.
Br J Pharmacol 2005;289:H533
Central and peripheral components of the pressor effect of anandamide in urethane-anaesthetized rats.
Authors: Kwolek Et al.
Br J Pharmacol 2005;145:567
Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons.
Authors: Price Et al.
Br J Pharmacol 2004;142:257
Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways.
Authors: Movsesyan Et al.
Br J Pharmacol 2004;11:1121
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Authors: Bátkai Et al.
Eur J Pharmacol 2004;110:1996
'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism.
Authors: Smart Et al.
J Biomol Screen 2002;136:452
Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats.
Authors: Jamshidi and Taylor
Br J Pharmacol 2001;134:1151
Differences in the pharmacological properties of rat and chicken brain fatty acid amidohydrolase.
Authors: Fowler Et al.
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