PMX 53 (CAS 219639-75-5): R&D Systems
Catalog Number: 5473
Biological Activity
Potent C5a receptor antagonist (IC50 = 20 nM). Also MrgX2 agonist. Stimulates MrgX2-mediated mast cell degranulation. Also inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis.
Technical Data
  • M.Wt:
    896.1
  • Formula:
    C47H65N11O7
  • Sequence:
    FXPXWR

    (Modifications: Phe-1 = N-terminal Ac, X-2 = Orn, X-4 = D-Cha, Lactam bridge: Orn-2 to Arg-6 )

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    219639-75-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Role of complement C5a in mechanical inflammatory hypernociception: potential use of C5a receptor antagonists to control inflammatory pain.
    Ting et al.
    Br.J.Pharmacol., 2008;153:1043
  2. PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells.
    Subramanian et al.
    Mol.Pharmacol., 2011;79:1005
  3. Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a.
    Finch et al.
    J.Med.Chem., 1999;42:1965
  4. Complement c5a receptor facilitates cancer metastasis by altering T-cell responses in the metastatic niche.
    Vadrevu et al.
    Cancer Res., 2014;74:3454
  5. Complement C5a inhibition reduces atherosclerosis in ApoE-/- mice.
    Manthey et al.
    FASEB J, 2011;25:2447
Tocris Peptides
Description Application Cat# Citations Images  

PMX 53c

5697  
View Sizes & Prices
Catalog# Size Price Stock Quantity
Loading Information....

Have you used PMX 53?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

or select another batch: 

Feedback

Customer Information