PMX 53

Catalog # Availability Size / Price Qty
5473/1
Cat.No. 5473 - PMX 53 | Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg) | CAS No. 219639-75-5
1 Image
Description: Potent C5a receptor antagonist
Product Details
Citations (1)
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Biological Activity

Potent C5a receptor antagonist (IC50 = 20 nM). Also MrgX2 agonist. Stimulates MrgX2-mediated mast cell degranulation. Also inhibits C5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis.

Negative Control also available.

Technical Data

M.Wt:
896.1
Formula:
C47H65N11O7
Sequence:
FXPXWR

(Modifications: Phe-1 = N-terminal Ac, X-2 = Orn, X-4 = D-Cha, Lactam bridge: Orn-2 to Arg-6 )

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
219639-75-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

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Citation for PMX 53

The citations listed below are publications that use Tocris products. Selected citations for PMX 53 include:

1 Citation: Showing 1 - 1

  1. Orthosteric and allosteric action of the C5a receptor antagonists.
    Authors: Liu
    Nat Struct Mol Biol  2018;25:472

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