Positive allosteric modulator of α
7 neuronal nicotinic acetylcholine receptors (EC50
= 216 nM), with no detectable effect on α
4 and α
10 receptors. Active in vivo
following systemic administration. Neuroprotective in an in vivo
model of transient focal cerebral ischemia.
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A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.
Hurst et al.
An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo.
Timmermann et al.
A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischemia.
Kalappa et al.
Br.J.Pharmacol. [Epub ahead of print], 2013;
The citations listed below are publications that use Tocris products. Selected citations for PNU 120596 include:
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