PNU 120596

  ( 11 citations )    
Product Datasheet
Catalog Number:2498
Chemical Name:N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea
Product Details
Citations (11)
Supplemental Products
Reviews
Biological Activity
Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (EC50 = 216 nM), with no detectable effect on α4β2, α3β4 and α9α10 receptors. Active in vivo following systemic administration. Neuroprotective in an in vivo model of transient focal cerebral ischemia.
Technical Data
  • M.Wt:
    311.72
  • Formula:
    C13H14ClN3O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    501925-31-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PNU 120596 include:

11 Citations: Showing 1 - 10
Filter your results:

  1. Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors.
    Authors: daCosta Et al.
    J Neurosci  2015;6:8057
  2. Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
    Authors: John Et al.
    PLoS One  2015;1601:15
  3. 6-bromohypaphorine from marine nudibranch mollusk Hermissenda crassicornis is an agonist of human α7 nicotinic acetylcholine receptor.
    Authors: Kasheverov Et al.
    Mar Drugs  2015;13:1255
  4. Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor.
    Authors: Zhang Et al.
    Mol Pharmacol  2015;10:e0137588
  5. α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties.
    Authors: Thomsen Et al.
    PLoS One  2015;10:e0130572
  6. Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons.
    Authors: Chatzidaki Et al.
    PLoS One  2015;10:e0125116
  7. A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages.
    Authors: Maldifassi Et al.
    PLoS One  2014;9:e108397
  8. Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT?a receptor antagonist.
    Authors: Pandya and Yakel
    Neuropharmacology  2013;70:35
  9. Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates.
    Authors: Yamauchi Et al.
    Nat Commun  2012;82:687
  10. Pharmacological characterization of native α7 nicotinic ACh receptors and their contribution to depolarization-elicited exocytosis in human chromaffin cells.
    Authors: P&eacuterez-Alvarez Et al.
    Br J Pharmacol  2012;165:908
  11. Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes.
    Authors: David Et al.
    Eur J Neurosci  2010;31:978
Expand to show all Citations

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used PNU 120596?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee