Chemical Name: N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea
Biological ActivityPNU 120596 is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (EC50 = 216 nM), with no detectable effect on α4β2, α3β4 and α9α10 receptors. Active in vivo following systemic administration. Neuroprotective in an in vivo model of transient focal cerebral ischemia.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.
Hurst et al.
An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo.
Timmermann et al.
A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischemia.
Kalappa et al.
Br.J.Pharmacol. [Epub ahead of print], 2013;
Citations for PNU 120596
The citations listed below are publications that use Tocris products. Selected citations for PNU 120596 include:
15 Citations: Showing 1 - 10
Structure and gating mechanism of the α7 nicotinic acetylcholine receptor.
Authors: Noviello Et al.
Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo.
Authors: Bali Et al.
Sci Rep 2019;9:9324
Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity.
Authors: Barykin Et al.
Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens.
Authors: Gimenz-Gomez Et al.
Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors.
Authors: daCosta Et al.
J Neurosci 2015;6:8057
Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
Authors: John Et al.
PLoS One 2015;1601:15
6-bromohypaphorine from marine nudibranch mollusk Hermissenda crassicornis is an agonist of human α7 nicotinic acetylcholine receptor.
Authors: Kasheverov Et al.
Mar Drugs 2015;13:1255
Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor.
Authors: Zhang Et al.
Mol Pharmacol 2015;10:e0137588
α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties.
Authors: Thomsen Et al.
PLoS One 2015;10:e0130572
Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons.
Authors: Chatzidaki Et al.
PLoS One 2015;10:e0125116
A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages.
Authors: Maldifassi Et al.
PLoS One 2014;9:e108397
Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT?a receptor antagonist.
Authors: Pandya and Yakel
Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates.
Authors: Yamauchi Et al.
Nat Commun 2012;82:687
Pharmacological characterization of native α7 nicotinic ACh receptors and their contribution to depolarization-elicited exocytosis in human chromaffin cells.
Authors: Pérez-Alvarez Et al.
Br J Pharmacol 2012;165:908
Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes.
Authors: David Et al.
Eur J Neurosci 2010;31:978
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for PNU 120596
There are currently no reviews for this product. Be the first to review PNU 120596 and earn rewards!
Have you used PNU 120596?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image