PNU 120596

Catalog # Availability Size / Price Qty
2498/5
2498/25
PNU 120596 | CAS No. 501925-31-1 | Nicotinic (a7) Receptor Modulators
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Description: Positive allosteric modulator of α7 nAChRs; active in vivo

Chemical Name: N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea

Purity: ≥99%

Product Details
Citations (13)
Supplemental Products
Reviews

Biological Activity

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (EC50 = 216 nM), with no detectable effect on α4β2, α3β4 and α9α10 receptors. Active in vivo following systemic administration. Neuroprotective in an in vivo model of transient focal cerebral ischemia.

Technical Data

M.Wt:
311.72
Formula:
C13H14ClN3O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
501925-31-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PNU 120596

The citations listed below are publications that use Tocris products. Selected citations for PNU 120596 include:

13 Citations: Showing 1 - 10

  1. Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo.
    Authors: Bali Et al.
    Sci Rep  2019;9:9324
  2. Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity.
    Authors: Barykin Et al.
    Cells  2019;8
  3. Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors.
    Authors: daCosta Et al.
    J Neurosci  2015;6:8057
  4. Functional α7 nicotinic receptors are expressed on immature granule cells of the postnatal dentate gyrus.
    Authors: John Et al.
    PLoS One  2015;1601:15
  5. 6-bromohypaphorine from marine nudibranch mollusk Hermissenda crassicornis is an agonist of human α7 nicotinic acetylcholine receptor.
    Authors: Kasheverov Et al.
    Mar Drugs  2015;13:1255
  6. Functional Impact of 14 Single Nucleotide Polymorphisms Causing Missense Mutations of Human α7 Nicotinic Receptor.
    Authors: Zhang Et al.
    Mol Pharmacol  2015;10:e0137588
  7. α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties.
    Authors: Thomsen Et al.
    PLoS One  2015;10:e0130572
  8. Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons.
    Authors: Chatzidaki Et al.
    PLoS One  2015;10:e0125116
  9. A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages.
    Authors: Maldifassi Et al.
    PLoS One  2014;9:e108397
  10. Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT?a receptor antagonist.
    Authors: Pandya and Yakel
    Neuropharmacology  2013;70:35

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