PP 1

Key Product Details

Product Description

PP 1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56^lck and p59^fynT (IC₅₀ values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.

Product Specifications for PP 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PP 1

The following data is based on the product molecular weight 281.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	35.54 mL	177.71 mL	355.42 mL
0.5 mM	7.11 mL	35.54 mL	71.08 mL
1 mM	3.55 mL	17.77 mL	35.54 mL
5 mM	0.71 mL	3.55 mL	7.11 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 15 publications citing the usage of this product.

• Tatton The src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases. J.Biol.Chem. 2003 PMID: 12475982
• Liu Structural basis for selective inhibition of Src family kinases by PP1. Chem.Biol. 1999 PMID: 10467133
• Carlomagno The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes. Cancer Res. 2002 PMID: 11861385
• Hanke Discovery of a novel, potent, and src family-selective tyrosine kinase inhibitor. J.Biol.Chem. 1996 PMID: 8557675
• Bain The specificities of protein kinase inhibitors: an update. Biochem.J. 2003 PMID: 12534346

Product Documents for PP 1