PP 1

Catalog # Availability Size / Price Qty
1397/10
PP 1 | CAS No. 172889-26-8 | Src Family Kinase Inhibitors
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Description: Potent, selective Src family kinase inhibitor

Chemical Name: 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Purity: ≥99%

Product Details
Citations (13)
Reviews

Biological Activity

Potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.

Technical Data

M.Wt:
281.36
Formula:
C16H19N5
Solubility:
Soluble to 10 mM in DMSO and to 10 mM in ethanol
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
172889-26-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PP 1

The citations listed below are publications that use Tocris products. Selected citations for PP 1 include:

13 Citations: Showing 1 - 10

  1. Pancreatic Ins content regulation by the estrogen receptor ER alpha.
    Authors: Alonso-Magdalena Et al.
    PLoS One  ;3:e2069
  2. Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes.
    Authors: Kurz Et al.
    Sci Rep  2019;9:747
  3. Chemerin-induced arterial contraction is Gi- and calcium-dependent.
    Authors: Ferland Et al.
    Vascul Pharmacol  2017;88:30
  4. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor.
    Authors: Lotz-Jenne Et al.
    Oncotarget  2016;7:25983
  5. Human NK cell development requires CD56-mediated motility and formation of the developmental synapse.
    Authors: Mace Et al.
    Nat Commun  2016;7:12171
  6. Receptor protein tyrosine phosphatase β/ζ is a functional binding partner for vascular endothelial growth factor.
    Authors: Koutsioumpa Et al.
    Front Syst Neurosci  2015;14:19
  7. Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells.
    Authors: Pham Et al.
    Pancreas  2012;41:1306
  8. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
  9. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
    Authors: Hildebrand Et al.
    J Neurosci  2009;29:9668
  10. NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells.
    Authors: Eum Et al.
    Toxicol Appl Pharmacol  2009;240:299

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