Catalog Number: 1397
Chemical Name: 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Biological Activity
Potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.
Technical Data
  • M.Wt:
    281.36
  • Formula:
    C16H19N5
  • Solubility:
    Soluble to 10 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    172889-26-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The specificities of protein kinase inhibitors: an update.
    Bain et al.
    Biochem.J., 2003;371:199
  2. The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes.
    Carlomagno et al.
    Cancer Res., 2002;62:1077
  3. Discovery of a novel, potent, and src family-selective tyrosine kinase inhibitor.
    Hanke et al.
    J.Biol.Chem., 1996;271:695
  4. Structural basis for selective inhibition of Src family kinases by PP1.
    Liu et al.
    Chem.Biol., 1999;6:671
  5. The src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.
    Tatton et al.
    J.Biol.Chem., 2003;278:4847
Citations:

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