Potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck
values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The specificities of protein kinase inhibitors: an update.
Bain et al.
The kinase inhibitor PP1 blocks tumorigenesis induced by RET oncogenes.
Carlomagno et al.
Cancer Res., 2002;62:1077
Discovery of a novel, potent, and src family-selective tyrosine kinase inhibitor.
Hanke et al.
Structural basis for selective inhibition of Src family kinases by PP1.
Liu et al.
The src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.
Tatton et al.
The citations listed below are publications that use Tocris products. Selected citations for PP 1 include:
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