PP 1

  ( 9 citations )    
Product Datasheet
Catalog Number:1397
Chemical Name:1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Product Details
Citations (9)
Reviews
Biological Activity
Potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl.
Technical Data
  • M.Wt:
    281.36
  • Formula:
    C16H19N5
  • Solubility:
    Soluble to 10 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    172889-26-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for PP 1 include:

9 Citations: Showing 1 - 9
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  1. Pancreatic insulin content regulation by the estrogen receptor ER alpha.
    Authors: Alonso-Magdalena Et al.
    PLoS One  ;3:e2069
  2. A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor.
    Authors: Lotz-Jenne Et al.
    Oncotarget  2016;7:25983
  3. Receptor protein tyrosine phosphatase β/ζ is a functional binding partner for vascular endothelial growth factor.
    Authors: Koutsioumpa Et al.
    Front Syst Neurosci  2015;14:19
  4. Apigenin inhibits NNK-induced focal adhesion kinase activation in pancreatic cancer cells.
    Authors: Pham Et al.
    Pancreas  2012;41:1306
  5. β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons.
    Authors: Meitzen Et al.
    J Neurochem  2011;116:984
  6. Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines.
    Authors: Hildebrand Et al.
    J Neurosci  2009;29:9668
  7. Integrin alpha(v)beta(3) is a pleiotrophin receptor required for pleiotrophin-induced endothelial cell migration through receptor protein tyrosine phosphatase beta/zeta.
    Authors: Mikelis Et al.
    FASEB J  2009;23:1459
  8. Transforming growth factor-beta1 effects on endothelial monolayer permeability involve focal adhesion kinase/Src.
    Authors: Lee Et al.
    Am J Respir Cell Mol Biol  2007;37:485
  9. SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines.
    Authors: Zhang Et al.
    Mol Cancer  2007;170:366

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