Selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck
values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50
= 0.73 μ
M). Negative control PP 3
(Cat. No. 2794) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
The specificities of protein kinase inhibitors: an update.
Bain et al.
Protein kinase inhibitors: the tyrosine-specific protein kinases.
Lawrence and Niu
Discovery of a novel, potent, and src family-selective tyrosine kinase inhibitor.
Hanke et al.
A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus.
Sanna et al.
The citations listed below are publications that use Tocris products. Selected citations for PP 2 include:
Showing Results 1 - 10 of 32