Catalog Number: 2794
Chemical Name: 1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Biological Activity
Negative control for the Src kinase inhibitor, PP 2. Inhibits EGFR kinase (IC50 = 2.7 μM).

Active Analog also available.

Technical Data
  • M.Wt:
    211.22
  • Formula:
    C11H9N5
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    5334-30-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines.
    Traxler et al.
    J.Med.Chem., 1997;40:3601
  2. PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia.
    Hou et al.
    Neurosci.Letts., 2007;420:235
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PP 3 include:

4 Citations: Showing 1 - 4
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  1. Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages.
    Authors: Vijayakumar Et al.
    Neural Regen Res 2015;128:251
  2. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One 2014;9:e106316
  3. Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue.
    Authors: Rosas Et al.
    Cell 2014;9:2164
  4. Reelin signaling specifies the molecular identity of the pyramidal neuron distal dendritic compartment.
    Authors: Kupferman Et al.
    J Neuroimmune Pharmacol 2014;158:1335
Tocris Small Molecules
Description Application Cat# Citations Images  

PP 2

1407 33  
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