Catalog Number: 3870
Chemical Name: (S*,R*)-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylic acid methyl ester
Biological Activity
Selective sigma (σ) receptor ligand. Displays high affinity for σ1; also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT.
Technical Data
  • M.Wt:
    469.53
  • Formula:
    C24H29NO3.C2H2O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    932736-91-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Anti-amnesic properties of (±)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats.
    Antonini et al.
    J.Neurochem., 2009;109:744
  2. Novel sigma receptor ligands: synthesis and biological profile.
    Prezzavento et al.
    J.Med.Chem., 2007;50:951
  3. A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect.
    Prezzavento et al.
    Life Sci., 2008;82:549
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (±)-PPCC oxalate include:

1 Citations: Showing 1 - 1

  1. The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice.
    Authors: Malik Et al.
    J Biol Chem 2015;172:2519

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