Catalog Number: 2530
Chemical Name: (2S*,3R*)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylic acid
Biological Activity
Subtype-selective NMDA receptor antagonist that preferentially binds to NR2C/NR2D-containing receptors (Ki values are 0.096, 0.125, 0.31 and 0.55 μM for NR2C, NR2D, NR2B and NR2A subunits respectively).
Technical Data
  • M.Wt:
    378.38
  • Formula:
    C21H18N2O5
  • Solubility:
    Soluble to 50 mM in 2eq. NaOH and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    684283-16-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from UNeMed Corporation.
Background References
  1. Identification of subunit- and antagonist-specific amino acid residues in the N-methyl-D-aspartate receptor glutamate-binding pocket.
    Kinarsky et al.
    J.Pharmacol.Exp.Ther., 2005;313:1066
  2. Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid.
    Feng et al.
    Br.J.Pharmacol., 2004;141:508
  3. Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists.
    Morley et al.
    J.Med.Chem., 2005;48:2627
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PPDA include:

2 Citations: Showing 1 - 2
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  1. Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.
    Authors: Mirante Et al.
    Autophagy 2014;7:62
  2. Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons.
    Authors: Ferando and Mody
    Front Neural Circuits 2013;7:144

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