PPDA

Key Product Details

Product Description

PPDA is a subtype-selective NMDA receptor antagonist that preferentially binds to GluN2C/GluN2D (formally NR2C/NR2D) containing receptors (K_i values are 0.096, 0.125, 0.31 and 0.55 μM for GluN2C, GluN2D, GluN2B and GluN2A subunits respectively).

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Licensing Information

Sold under license from UNeMed Corporation.

Product Specifications for PPDA

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PPDA

The following data is based on the product molecular weight 378.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.64 mL	13.21 mL	26.43 mL
5 mM	0.53 mL	2.64 mL	5.29 mL
10 mM	0.26 mL	1.32 mL	2.64 mL
50 mM	0.05 mL	0.26 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 33 publications citing the usage of this product.

• Morley Synthesis and pharmacology of N₁-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J.Med.Chem. 2005 PMID: 15801853
• Kinarsky Identification of subunit- and antagonist-specific amino acid residues in the N-MthD.-aspartate receptor glutamate-binding pocket. J.Pharmacol.Exp.Ther. 2005 PMID: 15743930
• Feng Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid. Br.J.Pharmacol. 2004 PMID: 14718249

Product Documents for PPDA