Catalog Number: 1309
Chemical Name: Pyridoxal-5'-phosphate-6-(2'-naphthylazo-6'-nitro-4',8'-disulfonate) tetrasodium salt
Biological Activity
Potent and selective P2X1 receptor antagonist (pKB = 7.43 in rat vas deferens). Up to 52-fold selective over P2Y1 receptors, and selective over ecto-nucleotidase, α1A-adrenoceptors, A1, A2B, H1 and M3 receptors.
Technical Data
  • M.Wt:
    694.36
  • Formula:
    C18H11N4Na4O14PS2
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    1021868-77-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X1 receptors.
    Lambrecht et al.
    Eur.J.Pharmacol., 2000;387:R19
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PPNDS include:

1 Citations: Showing 1 - 1

  1. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.
    Authors: Madoux Et al.
    Biopolymers 2014;102:396

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