PPTN hydrochloride

Tocris Bioscience | Catalog # 4862

High affinity and selective P2Y14 antagonist
Tocris Bioscience

Key Product Details

Description

High affinity and selective P2Y14 antagonist
View all P2Y Receptor Antagonists »

Product Description

PPTN hydrochloride is a high affinity and selective P2Y14 antagonist (KB = 434 pM), which exhibits >10,000-fold selectivity for P2Y14 over other P2Y receptors. PPTN inhibits UDP-glucose and MRS 2690-induced porcine pancreatic artery contraction ex vivo, and also blocks UDP-glucose-induced chemotaxis of HL-60 leukemia cells in vitro.

External Portal Information

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PPTN is reviewed.

Product Specifications for PPTN hydrochloride

Molecular Weight

511.96

Formula

C29H24F3NO2.HCl

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid hydrochloride

CAS Number

1992047-65-0

PubChem ID

121513852

InChI Key

FKMVYPCBLWYNAV-UHFFFAOYSA-N

SMILES

FC(F)(F)C(C=C4)=CC=C4C1=CC=C(C(C3=CC=C(C5CCNCC5)C=C3)=CC(C(O)=O)=C2)C2=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.2 100
Ethanol 10.24 20

Preparing Stock Solutions for PPTN hydrochloride

The following data is based on the product molecular weight 511.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.77 mL 19.53 mL
5 mM 0.39 mL 1.95 mL 3.91 mL
10 mM 0.20 mL 0.98 mL 1.95 mL
50 mM 0.04 mL 0.20 mL 0.39 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Product Documents for PPTN hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PPTN hydrochloride

For research use only

Related Research Areas

Bioactive Lipids and Receptors

Citations for PPTN hydrochloride

Customer Reviews for PPTN hydrochloride (1)

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  • P2Y14 antagonist
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 09/20/2018
    Incubation and during agonist treatment

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