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PPTN hydrochloride

Catalog #: 4862 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4862/10
PPTN hydrochloride | CAS No. 1992047-65-0 | P2Y Receptor Antagonists
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Description: High affinity and selective P2Y14 antagonist

Chemical Name: 4-[4-(4-Piperidinyl)phenyl]-7-[4-(trifluoromethyl)phenyl]-2-naphthalenecarboxylic acid hydrochloride

Purity: ≥98%

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Biological Activity

PPTN hydrochloride is a high affinity and selective P2Y14 antagonist (KB = 434 pM), which exhibits >10,000-fold selectivity for P2Y14 over other P2Y receptors. PPTN inhibits UDP-glucose and MRS 2690-induced porcine pancreatic artery contraction ex vivo, and also blocks UDP-glucose-induced chemotaxis of HL-60 leukemia cells in vitro.

External Portal Information

The Chemical Probes pages of the Structural Genomics Consortium website are a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PPTN is reviewed.

Technical Data

M.Wt:
511.96
Formula:
C29H24F3NO2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1992047-65-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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VersaClone cDNA Plasmids

Human P2Y14/GPR105 (NP_055694) VersaClone cDNA

RDC0378

Mouse P2Y14/GPR105 (NP_573463) VersaClone cDNA

RDC0672

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