Potent inhibitor of T315l mutant and wild-type Abl kinases (IC50
values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.
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Crystal structure of the T315I mutant of AbI kinase.
Zhou et al.
Inhibitors of ABL and the ABL-T315I mutation.
Noronha et al.