Catalog # Availability Size / Price Qty
PPY A | CAS No. 875634-01-8 | Abl Kinase Inhibitors
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Description: Potent inhibitor of Abl T315l mutant and wild-type Abl kinases

Chemical Name: 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide

Product Details

Biological Activity

Potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.

Technical Data

Soluble to 100 mM in DMSO
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Crystal structure of the T315I mutant of AbI kinase.
    Zhou et al.
    Chem.Biol.Drug.Des., 2007;70:171
  2. Inhibitors of ABL and the ABL-T315I mutation.
    Noronha et al.
    Curr.Top.Med.Chem., 2008;8:905

Product Datasheets

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