Catalog Number: 4730
Chemical Name: 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide
Biological Activity
Potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.
Technical Data
  • M.Wt:
    372.42
  • Formula:
    C22H20N4O2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    875634-01-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Crystal structure of the T315I mutant of AbI kinase.
    Zhou et al.
    Chem.Biol.Drug.Des., 2007;70:171
  2. Inhibitors of ABL and the ABL-T315I mutation.
    Noronha et al.
    Curr.Top.Med.Chem., 2008;8:905

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