Catalog Number: 6317
Alternate Names: LY640315, CS 747, Effient
Chemical Name: 2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone
Biological Activity
Irreversible P2Y12 antagonist; metabolised to active metabolite R-99224 (IC50 = 45 μM) irreversibly binds platelet P2Y12 receptors, inhibiting platelet activation. Antiplatelet and antithrombotic. Orally active and active in vivo. Note - inactive in vitro.
Technical Data
  • M.Wt:
    373.44
  • Formula:
    C20H20FNO3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    150322-43-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties.
    Sugidachi et al.
    Br.J.Pharmacol., 2000;129:1439
  2. The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of prasugrel in a mouse model: evidence for specific inhibition of P2Y12 receptors by prasugrel.
    Hashimoto
    Biochem.Pharmacol., 2007;74:1003
  3. Prasugrel.
    Huber et al.
    Nat.Rev.Drug Discov., 2009;8:449

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