Catalog Number: 0623
Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride
Biological Activity
α1 and α2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). Also available as part of the α1-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™.
Technical Data
  • M.Wt:
    419.87
  • Formula:
    C19H21N5O4.HCl
  • Solubility:
    Soluble to 25 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    19237-84-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Prazosin inhibits MK-801-induced hyperlocomotion and dopamine release in the nucleus accumbens.
    Mathe et al.
    Eur.J.Pharmacol., 1996;309:1
  2. Characterisation of 2-[125I]iodomelatonin binding sites in syrian hamster peripheral organs.
    Paul et al.
    J.Pharmacol.Exp.Ther., 1999;290:334
  3. Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus.
    Pickering and Niles
    Eur.J.Pharmacol., 1990;175:71
  4. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
Citations:

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