Prazosin hydrochloride

Key Product Details

Product Description

Prazosin hydrochloride is an α₁ and α_2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT₃ receptor (K_i = 10.2 nM). In prostate cancer cells, Prazosin induces DNA damage stress, Cdk1 inactivation, G₂ checkpoint arrest and apoptosis. In mice bearing prostate cancer xenografts, oral administration of Prazosin reduces tumor mass.

Product Specifications for Prazosin hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Prazosin hydrochloride

The following data is based on the product molecular weight 419.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.53 mL	47.63 mL	95.27 mL
1.25 mM	1.91 mL	9.53 mL	19.05 mL
2.5 mM	0.95 mL	4.76 mL	9.53 mL
12.5 mM	0.19 mL	0.95 mL	1.91 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 56 publications citing the usage of this product.

• Lin Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle. Neoplasia 2007 PMID: 17971903
• Paul Characterisation of 2-[¹²⁵I]iodomelatonin binding sites in syrian hamster peripheral organs. J.Pharmacol.Exp.Ther. 1999 PMID: 10381796
• Pickering and Niles Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus. Eur.J.Pharmacol. 1990 PMID: 2157597
• Mathe Prazosin inhibits MK-801-induced hyperlocomotion and DA release in the nucleus accumbens. Eur.J.Pharmacol. 1996 PMID: 8864686

Product Documents for Prazosin hydrochloride