Prazosin hydrochloride

  ( 11 citations )    
Product Datasheet
Catalog Number:0623
Chemical Name:1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride
Product Details
Citations (11)
Supplemental Products
Reviews
Biological Activity
α1 and α2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). Also available as part of the α1-Adrenoceptor Tocriset™ and Mixed Adrenergic Tocriset™.
Technical Data
  • M.Wt:
    419.87
  • Formula:
    C19H21N5O4.HCl
  • Solubility:
    Soluble to 25 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    19237-84-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Prazosin hydrochloride include:

11 Citations: Showing 1 - 10
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  1. The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
    Authors: Kahn Et al.
    EMBO Mol Med  2016;8:511
  2. Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels.
    Authors: Delaney and Crane
    Sci Rep  2016;6:19255
  3. Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.
    Authors: Skelly and Weiner
    Brain Behav  2014;4:468
  4. Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.
    Authors: Corcoran Et al.
    Pain  2014;34:51
  5. Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
    Authors: Hughes Et al.
    J Clin Invest  2013;154:1680
  6. Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats.
    Authors: Tjen-A-Looi Et al.
    Am J Physiol Heart Circ Physiol  2011;300:H1003
  7. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology  2011;152:3842
  8. Blockade of adrenoreceptors inhibits the splenic response to stroke.
    Authors: Ajmo Et al.
    Cell Rep  2009;218:47
  9. Tyramine excites rat subthalamic neurons in vitro by a dopamine-dependent mechanism.
    Authors: Zhu Et al.
    Neuropharmacology  2007;52:1169
  10. Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.
    Authors: Moura Et al.
    Br J Pharmacol  2006;149:1049
  11. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
    Authors: Sjöblom Et al.
    Exp Neurol  2001;108:625
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