Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride
Biological ActivityPrazosin hydrochloride is an α1 and α2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). In prostate cancer cells, Prazosin induces DNA damage stress, Cdk1 inactivation, G2 checkpoint arrest and apoptosis. In mice bearing prostate cancer xenografts, oral administration of Prazosin reduces tumor mass.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303
Characterisation of 2-[125I]iodomelatonin binding sites in syrian hamster peripheral organs.
Paul et al.
Prazosin inhibits MK-801-induced hyperlocomotion and DA release in the nucleus accumbens.
Mathe et al.
Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus.
Pickering and Niles
Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle.
Lin et al.
Citations for Prazosin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Prazosin hydrochloride include:
12 Citations: Showing 1 - 10
The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
Authors: Kahn Et al.
EMBO Mol Med 2016;8:511
Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels.
Authors: Delaney and Crane
Sci Rep 2016;6:19255
Chronic treatment with pra. or dulox. lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.
Authors: Skelly and Weiner
Brain Behav 2014;4:468
Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.
Authors: Corcoran Et al.
Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
Authors: Hughes Et al.
J Clin Invest 2013;154:1680
Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats.
Authors: Tjen-A-Looi Et al.
Am J Physiol Heart Circ Physiol 2011;300:H1003
NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
Authors: Zemkova Et al.
Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
Authors: Huang Et al.
Blockade of adrenoreceptors inhibits the splenic response to stroke.
Authors: Ajmo Et al.
Cell Rep 2009;218:47
Tyramine excites rat subthalamic neurons in vitro by a DA-dependent mechanism.
Authors: Zhu Et al.
Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.
Authors: Moura Et al.
Br J Pharmacol 2006;149:1049
Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
Authors: Sjöblom Et al.
Exp Neurol 2001;108:625
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for Prazosin hydrochloride
There are currently no reviews for this product. Be the first to review Prazosin hydrochloride and earn rewards!
Have you used Prazosin hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image