Catalog # Availability Size / Price Qty
preQ1-alkyne | CAS No. 2771096-76-3 | CRISPR Reagents
1 Image
Description: preQ1 with alkyne handle for click chemistry

Chemical Name: N-[6-[[(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]amino]hexyl]-3-(2-propyn-1-yloxy)propanamide

Purity: ≥95%

Product Details

Biological Activity

preQ1-alkyne is a modified analog of the natural substrate prequeosine1 (preQ1). It contains alkyne handle that enables users to attach additional groups to preQ1 via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. It can be used to generate photoactivatable probes that can control CRISPR gene editing via the RNA-TAG method.

Other RNA-TAG toolbox compounds include preQ1-biotin (Cat. No. 7804)

Plasmids for expression of the E.coli TGT enzyme (#138201) and for cloning an RNA of interest into a vector containing the recognition motif at the 3' end (#138209) are available from Addgene.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from The Regents of the University of California.

Product Datasheets

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