Pritelivir

Key Product Details

Product Description

Pritelivir is a potent and selective herpes simplex virus (HSV) helicase primase inhibitor. Pritelivir inhibits viral replication in Vero cells (IC₅₀ = 0.02 μM for HSV-1 and HSV-2). It also reduces β-amyloid and P-tau levels in Vero cells. Pritelivir is active against clinical isolates and porcine and bovine HSV strains but displays reduced activity against varicella zoster virus and cytomegalovirus in vitro. In addition, the compound exhibits antiviral activity in HSV infected mice.

Product Specifications for Pritelivir

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Pritelivir

The following data is based on the product molecular weight 402.49.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.97 mL	24.85 mL	49.69 mL
2.5 mM	0.99 mL	4.97 mL	9.94 mL
5 mM	0.50 mL	2.48 mL	4.97 mL
25 mM	0.10 mL	0.50 mL	0.99 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wozniak The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer's disease-related molecules induced by herpes simplex virus type 1. Antiviral Res. 2013 PMID: 23867133
• Kleymann New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. Nat.Med. 2002 PMID: 11927946

Product Documents for Pritelivir