Catalog Number: 5151
Biological Activity
Potent GPR37L1 and GPR37 agonist (EC50 values are 5 and 7 nM, respectively). Stimulates signaling through pertussis toxin-sensitive G proteins. Stimulates ERK phosphorylation. Protects against cellular stress. Promotes myelin lipid synthesis and prolongs cell survival in both Schwann cells and oligodendrocytes; neuroprotective and glioprotective.
Technical Data
  • M.Wt:
    1579.72
  • Formula:
    C69H110N16O26
  • Sequence:
    TXLIDNNATEEILY

    (Modifications: Ala-2 = D-Ala)

  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Store at -20°C
  • CAS No:
    196391-82-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides.
    Hiraiwa et al.
    Proc.Natl.Acad.Sci.USA., 1997;94:4778
  2. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.
    Meyer et al.
    Proc.Natl.Acad.Sci.USA., 2013;110:9529

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