PROTAC®(H-PGDS)-7

Tocris Bioscience | Catalog # 8004

Potent hematopoietic prostaglandin D2 synthase Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Potent hematopoietic prostaglandin D2 synthase Degrader (PROTAC®)
View all Active Degraders »

Product Description

PROTAC®(H-PGDS)-7 is a potent Degrader of hematopoietic prostaglandin D2 synthase (H-PGDS; DC50 = 17pM after 24 hours). Comprises the H-PGDS inhibitor TFC-007 (Cat. No. 5108) directly linked to E3 ligase cereblon. Suppresses prostaglandin D2 production in vitro and in vivo.

PROTAC®(H-PGDS)-8 negative control (Cat. No. 8005) also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from National Institute of Health Sciences, Japan and Tsuzuki Gakuen.

Product Specifications for PROTAC®(H-PGDS)-7

Molecular Weight

742.79

Formula

C40H38N8O7

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-[4-[[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-1-piperazinyl]carbonyl]-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide

CAS Number

2761281-50-7

PubChem ID

162679258

InChI Key

KQNXUQJGOJWQGL-UHFFFAOYSA-N

SMILES

O=C(C1=CN=C(OC2=CC=CC=C2)N=C1)NC3=CC=C(N4CCC(CC4)C(N5CCN(CC5)C(C=CC=C6C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 74.28 100

Preparing Stock Solutions for PROTAC®(H-PGDS)-7

The following data is based on the product molecular weight 742.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.35 mL 6.73 mL 13.46 mL
5 mM 0.27 mL 1.35 mL 2.69 mL
10 mM 0.13 mL 0.67 mL 1.35 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PROTAC®(H-PGDS)-7

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PROTAC®(H-PGDS)-7

For research use only

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