Potent hematopoietic prostaglandin D synthase (H-PGDS) inhibitor (IC50
= 83 nM). Inhibits PGD2
production and late phase nasal blockage in an animal model of allergic rhinitis. Exhibits negligible effects on COX-1, COX-2, 5-LOX, LTC4
synthase and microsomal prostaglandin E2
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Inhibition of hematopoietic prostaglandin D synthase improves allergic nasal blockage in guinea pigs.
Nabe et al.
Prostaglandins Other Lipid Mediat., 2011;95:27