ProTx II

Name: ProTx II
Brand: Tocris Bioscience
SKU: 4023
Price: 230 USD
Availability: InStock

Tocris Bioscience | Catalog # 4023

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Citations (21)

Product Documents

Selective NaV1.7 channel blocker

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Selective NaV1.7 channel blocker

View all Voltage-gated Sodium Channel Blockers »

Product Description

ProTx II is a selective Na_V1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.

Product Specifications for ProTx II

Molecular Weight

3826.59

Formula

C₁₆₈H₂₅₀N₄₆O₄₁S₈

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

484598-36-9

PubChem ID

118708662

InChI Key

XOAUGYVLRSCGBG-ZJDFQAAZSA-N

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N3)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 21 publications citing the usage of this product.

Xu Structural basis of Na_v1.7 inhibition by a gating-modifier spider toxin. Cell. 2019 PMID: 30661758
Edgerton Evidence for multiple effects of ProTxII on activation gating in Na_V 1.5. Toxicon. 2008 PMID: 18657562
Schmalhofer ProTx-II, a selective inhibitor of Na_V 1.7 sodium channels, blocks action potential propagation in nociceptors. Mol.Pharmacol. 2008 PMID: 18728100
Smith Molecular interactions of the gating modifier toxin ProTx-II with Na_V 1.5: implied existence of a novel toxin binding site coupled to activation. J.Biol.Chem. 2007 PMID: 17339321

Product Documents for ProTx II

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for ProTx II

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for ProTx II

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