1.7 channel blocker. Shifts activation gating positively and decreases current magnitude. Displays 100-fold selectivity over other sodium channel subtypes.
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All Tocris products are intended for laboratory research use only.
Molecular interactions of the gating modifier toxin ProTx-II with NaV 1.5: implied existence of a novel toxin binding site coupled to activation.
Smith et al.
Evidence for multiple effects of ProTxII on activation gating in NaV 1.5.
Edgerton et al.
ProTx-II, a selective inhibitor of NaV 1.7 sodium channels, blocks action potential propagation in nociceptors.
Schmalhofer et al.